Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 2/20 | 0.56 |
| ▸ | FABP3 | P05413 | 1/20 | 0.56 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | APOB | P04114 | 2/20 | 0.47 |
| ▸ | MTTP | P55157 | 2/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28977089 | 0.89 | APOB (0.50) | FABP4FABP3FABP5LMNAAPOB | |
| SCHEMBL5845535 | 0.87 | FABP4 (0.70) | FABP4FABP3FABP5HTTCA12 | |
| SCHEMBL4983522 | 0.86 | FABP3 (0.57) | FABP4FABP3FABP5HTTCA12 | |
| SCHEMBL4988220 | 0.86 | FABP3 (0.57) | FABP4FABP3FABP5HTTCA12 | |
| SCHEMBL6695055 | 0.85 | FABP3 (0.53) | FABP4FABP3FABP5HTTCA12 | |
| SCHEMBL7463326 | 0.83 | FABP3 (0.55) | FABP4FABP3FABP5HTTCA12 | |
| SCHEMBL3230990 | 0.82 | FABP3 (0.53) | FABP4FABP3FABP5HTTLMNA | |
| SCHEMBL6501691 | 0.81 | FABP3 (0.52) | FABP4FABP3FABP5HTTCA12 | |
| SCHEMBL3282245 | 0.80 | CA12 (0.46) | FABP4LMNACA12CA1CA2 | |
| SCHEMBL6804369 | 0.79 | MYC (0.54) | FABP4HTTLMNAAPOBMTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040157866-A1 | Amide compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-12 | — | — | US | disclosed |
| US-20040121998-A1 | CRF antagonistic quino- and quinazolines | NEUROCRINE BIOSCIENCES, INC. | 2004-06-24 | — | — | US | disclosed |
| EP-0977737-B1 | CRF ANTAGONISTIC QUINO- AND QUINAZOLINES | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | disclosed |
| US-6610678-B2 | Corticotropin-releasing factor antagonists; treating endocrine, psychiatric or neurologic disorders | HUANG CHARLES (US) | 2003-08-26 | — | — | US | disclosed |
| US-20030119818-A1 | CRF antagonistic quino-and quinazolines | HUANG CHARLES (US) | 2003-06-26 | — | — | US | disclosed |
| US-6482836-B1 | CRF antagonistic quino- and quinazolines | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-11-19 | — | — | US | disclosed |
| EP-0977737-A1 | CRF ANTAGONISTIC QUINO- AND QUINAZOLINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998047874-A1 | CRF ANTAGONISTIC QUINO- AND QUINAZOLINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119818-A1 | CRF antagonistic quino-and quinazolines | CRHR1, HTR6, CRH | FABP4 3427/4885FABP3 2463/4885FABP5 3038/4885 |
| US-20040157866-A1 | Amide compounds | APOB, NR1H2, NR1H3 | FABP4 1206/4885FABP3 605/4885FABP5 1103/4885 |
| US-20040121998-A1 | CRF antagonistic quino- and quinazolines | CRHR1, HTR6, CRH | FABP4 3427/4885FABP3 2463/4885FABP5 3038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.