Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | DHFR | P00374 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672319 | 0.79 | DHFR (0.73) | CYP2D6DHFRSMN1; SMN2TP53HIF1A | |
| SCHEMBL14974477 | 0.77 | DHFR (0.60) | CYP2D6DHFRSMN1; SMN2TP53HIF1A | |
| SCHEMBL672323 | 0.71 | DHFR (0.74) | CYP2D6DHFRSMN1; SMN2TP53HIF1A | |
| SCHEMBL671214 | 0.71 | DHFR (1.00) | CYP2D6DHFRSMN1; SMN2TP53HIF1A | |
| SCHEMBL670848 | 0.70 | DHFR (0.71) | CYP2D6DHFRSMN1; SMN2TP53HIF1A | |
| SCHEMBL19951296 | 0.70 | KDM4E (0.59) | SMN1; SMN2ALDH1A1KDM4ETDP1TSHR | |
| SCHEMBL670955 | 0.70 | DHFR (0.67) | CYP2D6DHFRSMN1; SMN2TP53HIF1A | |
| SCHEMBL8802767 | 0.67 | TSHR (0.56) | SMN1; SMN2ALDH1A1KDM4ETDP1TSHR | |
| SCHEMBL2716970 | 0.67 | ALDH1A1 (0.73) | SMN1; SMN2ALDH1A1KDM4ETDP1MAPT | |
| SCHEMBL11619414 | 0.67 | TSHR (0.48) | SMN1; SMN2ALDH1A1KDM4ETDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11844802-B2 | Compounds and compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2023-12-19 | — | — | US | disclosed |
| US-20230044670-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | UNIV EMORY (US) | 2023-02-09 | — | — | US | disclosed |
| US-11471461-B2 | Compounds and compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2022-10-18 | — | — | US | disclosed |
| US-20210100806-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | UNIV EMORY (US) | 2021-04-08 | — | — | US | disclosed |
| US-10888565-B2 | Compounds and compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2021-01-12 | — | — | US | disclosed |
| US-20200121687-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | UNIV EMORY (US) | 2020-04-23 | — | — | US | disclosed |
| US-20180207166-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-07-26 | — | — | US | disclosed |
| US-9808464-B2 | Compounds and compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2017-11-07 | — | — | US | disclosed |
| EP-3187197-A1 | COMPOUNDS AND COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | Emory University (US) | 2017-07-05 | — | — | EP | disclosed |
| EP-2605804-B1 | COMPOUNDS AND COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | UNIV EMORY (US) | 2017-03-15 | — | — | EP | disclosed |
| US-20170035771-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-02-09 | — | — | US | disclosed |
| US-9511071-B2 | Compounds and compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2016-12-06 | — | — | US | disclosed |
| EP-2605804-A2 | COMPOUNDS AND COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | Emory University (US) | 2013-06-26 | — | — | EP | disclosed |
| US-20130137634-A1 | COMPOUNDS AND COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2013-05-30 | — | — | US | disclosed |
| WO-2012024489-A2 | COMPOUNDS AND COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2012-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10888565-B2 | Compounds and compositions for ossification and methods related thereto | BMP2, SOST, BMP4 | CYP2D6 3187/4885CYP1A2 3253/4885CYP2C19 4470/4885 |
| US-20130137634-A1 | COMPOUNDS AND COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | BMP2, SOST, BMP4 | CYP2D6 3187/4885CYP1A2 3253/4885CYP2C19 4470/4885 |
| US-20180207166-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | BMP2, SOST, BMP4 | CYP2D6 3187/4885CYP1A2 3253/4885CYP2C19 4470/4885 |
| US-11471461-B2 | Compounds and compositions for ossification and methods related thereto | BMP2, SOST, BMP4 | CYP2D6 3187/4885CYP1A2 3253/4885CYP2C19 4470/4885 |
| US-20230044670-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | BMP2, SOST, BMP4 | CYP2D6 3187/4885CYP1A2 3253/4885CYP2C19 4470/4885 |
| US-20210100806-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | BMP2, SOST, BMP4 | CYP2D6 3187/4885CYP1A2 3253/4885CYP2C19 4470/4885 |
| US-20170035771-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | BMP2, SOST, BMP4 | CYP2D6 3187/4885CYP1A2 3253/4885CYP2C19 4470/4885 |
| US-20200121687-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | BMP2, SOST, BMP4 | CYP2D6 3187/4885CYP1A2 3253/4885CYP2C19 4470/4885 |
| US-11844802-B2 | Compounds and compositions for ossification and methods related thereto | BMP2, SOST, BMP4 | CYP2D6 3187/4885CYP1A2 3253/4885CYP2C19 4470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.