Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.40 |
| ▸ | MMP2 | P08253 | 12/20 | 0.39 |
| ▸ | MMP3 | P08254 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 10/20 | 0.39 |
| ▸ | MMP14 | P50281 | 3/20 | 0.38 |
| ▸ | ADAM10 | O14672 | 3/20 | 0.38 |
| ▸ | MMP1 | P03956 | 3/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.38 |
| ▸ | MMP7 | P09237 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6722526 | 0.86 | MMP13 (0.41) | MMP13ADAMTS4MMP2MMP3LMNA | |
| SCHEMBL6722415 | 0.83 | DUT (0.44) | MMP13MMP2MMP3LMNAMMP9 | |
| SCHEMBL6719280 | 0.83 | MMP2 (0.39) | MMP13ADAMTS4MMP2MMP3LMNA | |
| SCHEMBL6722440 | 0.83 | MMP2 (0.40) | MMP13ADAMTS4MMP2MMP3LMNA | |
| SCHEMBL6723460 | 0.82 | MMP2 (0.41) | MMP13ADAMTS4MMP2MMP3LMNA | |
| SCHEMBL6719868 | 0.81 | MMP2 (0.45) | MMP13ADAMTS4MMP2MMP3MMP9 | |
| SCHEMBL6719618 | 0.81 | ADAM17 (0.37) | MMP13ADAMTS4MMP2MMP3MMP9 | |
| SCHEMBL6723629 | 0.77 | MMP2 (0.56) | MMP13ADAMTS4MMP2MMP3LMNA | |
| SCHEMBL6724130 | 0.77 | CTSS (0.47) | — | |
| SCHEMBL6722446 | 0.72 | MMP2 (0.52) | MMP13ADAMTS4MMP2MMP3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673804-B1 | PREVENTING OR TREATING ARTHRITIS (PARTICULARLY OSTEOARTHRITIS) OR INHIBITING METASTASIS, INVASION OR GROWTH OF CANCER (PARTICULARLY BREAST CANCER) | SANKYO COMPANY, LIMITED (JP) | 2004-01-06 | — | — | US | disclosed |
| EP-1069110-A1 | SULFONAMIDE DERIVATIVES | Sankyo Company Limited (JP) | 2001-01-17 | — | — | EP | disclosed |