Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24608781 | 0.88 | HSD11B1 (0.42) | HSD11B1GPR119ALDH1A1GRM5VNN1 | |
| SCHEMBL8808488 | 0.84 | AKT1 (0.37) | OPRM1HSD11B1GPR119ALDH1A1HPGD | |
| SCHEMBL7421566 | 0.82 | OPRM1 (0.65) | OPRM1HSD17B10 | |
| SCHEMBL7426632 | 0.79 | HSD11B1 (0.43) | OPRM1HSD11B1ALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL8353054 | 0.77 | HSD11B1 (0.42) | OPRM1HSD11B1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL8636435 | 0.77 | OPRM1 (0.44) | OPRM1HSD11B1ALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL6198508 | 0.76 | OPRM1 (0.44) | OPRM1HSD11B1ALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL8352985 | 0.76 | OPRM1 (0.44) | OPRM1HSD11B1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL23136323 | 0.76 | AKT1 (0.42) | OPRM1GPR119MAPK1MEN1CYP2D6 | |
| SCHEMBL16926658 | 0.76 | SLC6A9 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040138242-A1 | Dihydropyrimidines and uses thereof | MERCK AND CO., INC. | 2004-07-15 | — | — | US | disclosed |
| US-6680323-B2 | SELECTIVE ANTAGONISTS FOR HUMAN ALPHA 1A RECEPTORS; BENIGN PROSTATIC HYPERPLASIA; (+)-1-3-((4-(3,4-DIFLUOROPHENYL)-2,5-DIOXO-1,2,5,7-TETRAHYDRO-4H-FURO(3,4 -D)PYRIMIDINE-3-CARBONYL)AMINO)-PROPYL-4-(2-PYRIDYL)-PIPERIDINE | SYNAPTIC PHARMACEUTICAL CORPORATION | 2004-01-20 | — | — | US | disclosed |
| US-20010041707-A1 | Dihydropyrimidines and uses thereof | MERCK AND CO., INC | 2001-11-15 | — | — | US | disclosed |
| US-6274585-B1 | BENIGN PROSTATIC HYPERPLASIA TREATMENT | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138242-A1 | Dihydropyrimidines and uses thereof | QDPR, DPYD, ADRA1D | OPRM1 218/4885HSD11B1 1019/4885GPR119 97/4885 |
| US-20010041707-A1 | Dihydropyrimidines and uses thereof | QDPR, DPYD, ADRA1D | OPRM1 218/4885HSD11B1 1019/4885GPR119 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.