Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12852245 | 0.95 | MGLL (0.38) | MGLLPTGS1PTGS2FAAHHSP90AA1 | |
| SCHEMBL6727205 | 0.83 | PTGS1 (0.42) | MGLLPTGS1PTGS2FAAHHSP90AA1 | |
| SCHEMBL16405262 | 0.70 | MGLL (0.54) | MGLLPTGS1PTGS2FAAHHSP90AA1 | |
| SCHEMBL29044909 | 0.70 | MGLL (0.54) | MGLLPTGS1PTGS2FAAHHSP90AA1 | |
| SCHEMBL10052093 | 0.68 | MGLL (0.37) | MGLLPTGS1PTGS2ALDH1A1LMNA | |
| SCHEMBL6727206 | 0.68 | MGLL (0.33) | MGLLPTGS1PTGS2FAAH | |
| SCHEMBL23870259 | 0.68 | PTGS1 (0.44) | MGLLPTGS1PTGS2FAAHHSP90AA1 | |
| SCHEMBL16405264 | 0.65 | PTGS1 (0.63) | MGLLPTGS1PTGS2FAAHHSP90AA1 | |
| SCHEMBL17570363 | 0.65 | PTGS1 (0.48) | MGLLPTGS1PTGS2FAAHHSP90AA1 | |
| SCHEMBL12629199 | 0.65 | MGLL (0.62) | MGLLPTGS1PTGS2FAAHHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9636418-B2 | Potent and selective inhibitors of NAV1.7 | AMGEN INC. (US) | 2017-05-02 | — | — | US | disclosed |
| US-20160304570-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.3 AND NAV1.7 | AMGEN INC. (US) | 2016-10-20 | — | — | US | disclosed |
| US-9340590-B2 | Potent and selective inhibitors of NaV1.3 and NaV1.7 | AMGEN INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-20160024159-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | AMGEN INC. (US) | 2016-01-28 | — | — | US | disclosed |
| US-20150023988-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | AMGEN INC. (US) | 2015-01-22 | — | — | US | disclosed |
| US-20140073577-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.3 AND NAV1.7 | AMGEN INC. (US) | 2014-03-13 | — | — | US | disclosed |
| US-20130217625-A1 | COMPOSITIONS AND METHODS FOR PRODUCING BIOACTIVE FUSION PROTEINS | AMGEN INC. (US) | 2013-08-22 | — | — | US | disclosed |
| US-20120121591-A1 | SELECTIVE AND POTENT PEPTIDE INHIBITORS OF Kv1.3 | AMGEN INC. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217625-A1 | COMPOSITIONS AND METHODS FOR PRODUCING BIOACTIVE FUSION PROTEINS | HGFAC, HDGF, GRB2 | MGLL 4489/4885PTGS1 4059/4885PTGS2 4404/4885 |
| US-20140073577-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.3 AND NAV1.7 | SCN7A, SCN3A, SCN9A | MGLL 4473/4885PTGS1 3181/4885PTGS2 3564/4885 |
| US-20120121591-A1 | SELECTIVE AND POTENT PEPTIDE INHIBITORS OF Kv1.3 | KCNJ4, KCNK4, KCNQ4 | MGLL 3636/4885PTGS1 3442/4885PTGS2 3715/4885 |
| US-20150023988-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | SCN7A, SCN9A, SCN1A | MGLL 4337/4885PTGS1 2922/4885PTGS2 3218/4885 |
| US-20160024159-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | SCN7A, SCN9A, SCN1A | MGLL 4337/4885PTGS1 2922/4885PTGS2 3218/4885 |
| US-20160304570-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.3 AND NAV1.7 | SCN7A, SCN3A, SCN9A | MGLL 4473/4885PTGS1 3181/4885PTGS2 3564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.