Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6727209 | 0.95 | MGLL (0.37) | MGLLPTGS1PTGS2FAAHALDH1A1 | |
| SCHEMBL6727205 | 0.88 | PTGS1 (0.42) | MGLLPTGS1PTGS2FAAHALDH1A1 | |
| SCHEMBL29044909 | 0.74 | MGLL (0.54) | MGLLPTGS1PTGS2FAAHALDH1A1 | |
| SCHEMBL16405262 | 0.74 | MGLL (0.54) | MGLLPTGS1PTGS2FAAHALDH1A1 | |
| SCHEMBL23870259 | 0.72 | PTGS1 (0.44) | MGLLPTGS1PTGS2FAAHALDH1A1 | |
| SCHEMBL6727206 | 0.69 | MGLL (0.33) | MGLLPTGS1PTGS2FAAH | |
| SCHEMBL16405264 | 0.69 | PTGS1 (0.63) | MGLLPTGS1PTGS2FAAHALDH1A1 | |
| SCHEMBL17570363 | 0.69 | PTGS1 (0.48) | MGLLPTGS1PTGS2FAAHALDH1A1 | |
| SCHEMBL19546603 | 0.68 | MGLL (0.52) | MGLLPTGS1PTGS2FAAHALDH1A1 | |
| SCHEMBL6727208 | 0.66 | PTGS1 (0.46) | MGLLPTGS1PTGS2FAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807693-B2 | Apelin polypeptides | AMGEN INC. (US) | 2023-11-07 | — | — | US | disclosed |
| US-20170107255-A1 | APELIN POLYPEPTIDES | AMGEN INC. (US) | 2017-04-20 | — | — | US | disclosed |
| US-20160067347-A1 | APJ RECEPTOR AGONISTS AND USES THEREOF | AMGEN INC. (US) | 2016-03-10 | — | — | US | disclosed |
| US-20130209466-A1 | COMPOSITIONS AND METHODS FOR PRODUCING BIOACTIVE FUSION PROTEINS | AMGEN INC. (US) | 2013-08-15 | — | — | US | disclosed |
| US-8420779-B2 | Compositions and methods for producing bioactive fusion proteins | AMGEN INC. (US) | 2013-04-16 | — | — | US | disclosed |
| US-8288351-B2 | Antagonists of the bradykinin B1 receptor | AMGEN INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-8278280-B2 | Antagonists of the bradykinin B1 receptor | AMGEN INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-7605120-B2 | peptides and/or conjugated peptides may be used as therapeutics or prophylactics for the treatment of diseases mediated by B1 activation, including inflammation and chronic pain states of inflammatory and neuropathic origin, septic shock, arthritis, osteoarthritis, angina, asthma, allergic rhinitis | AMGEN INC. (US) | 2009-10-20 | — | — | US | disclosed |
| US-20090137483-A1 | Antagonists of the bradykinin B1 receptor | AMGEN INC. | 2009-05-28 | — | — | US | disclosed |
| US-20090137452-A1 | Antagonists of the bradykinin B1 receptor | AMGEN INC. | 2009-05-28 | — | — | US | disclosed |
| US-20090118181-A1 | Compositions and methods for producing bioactive fusion proteins | AMGEN INC. | 2009-05-07 | — | — | US | disclosed |
| US-20090048149-A1 | Antagonists of the bradykinin B1 receptor | AMGEN INC. | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048149-A1 | Antagonists of the bradykinin B1 receptor | BDKRB1, BDKRB2, LTB4R | MGLL 2155/4885PTGS1 220/4885PTGS2 654/4885 |
| US-20090118181-A1 | Compositions and methods for producing bioactive fusion proteins | HGFAC, HDGF, GRB2 | MGLL 4489/4885PTGS1 4059/4885PTGS2 4404/4885 |
| US-20090137452-A1 | Antagonists of the bradykinin B1 receptor | BDKRB1, BDKRB2, LTB4R | MGLL 2515/4885PTGS1 389/4885PTGS2 817/4885 |
| US-20090137483-A1 | Antagonists of the bradykinin B1 receptor | BDKRB1, BDKRB2, AVPR1B | MGLL 3049/4885PTGS1 296/4885PTGS2 664/4885 |
| US-20130209466-A1 | COMPOSITIONS AND METHODS FOR PRODUCING BIOACTIVE FUSION PROTEINS | HGFAC, HDGF, GRB2 | MGLL 4489/4885PTGS1 4059/4885PTGS2 4404/4885 |
| US-20170107255-A1 | APELIN POLYPEPTIDES | APLNR, FABP3, AP3B1 | MGLL 3340/4885PTGS1 3535/4885PTGS2 3850/4885 |
| US-11807693-B2 | Apelin polypeptides | APLNR, FABP3, AP3B1 | MGLL 3340/4885PTGS1 3535/4885PTGS2 3850/4885 |
| US-20160067347-A1 | APJ RECEPTOR AGONISTS AND USES THEREOF | APLNR, FABP3, AP2B1 | MGLL 3108/4885PTGS1 2699/4885PTGS2 2546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.