Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.51 |
| ▸ | RXRB | P28702 | 3/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.41 |
| ▸ | XDH | P47989 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6725240 | 0.86 | RXRA (0.51) | RXRARXRBAPP | |
| SCHEMBL5014148 | 0.83 | RXRA (0.62) | RXRARXRBNR4A2RAB9AL3MBTL1 | |
| SCHEMBL6724981 | 0.80 | SRD5A2 (0.49) | RXRARXRBNR4A2RAB9AL3MBTL1 | |
| SCHEMBL6728528 | 0.78 | RXRA (0.39) | RXRARXRBRXRGMAOBMRGPRX4 | |
| SCHEMBL29319558 | 0.75 | RXRA (0.62) | RXRARXRBNR4A2RAB9ANR4A1 | |
| SCHEMBL6725114 | 0.72 | MRGPRX4 (0.51) | NR4A2MAOBMRGPRX4 | |
| SCHEMBL6723656 | 0.72 | RXRA (0.64) | RXRARXRBNR4A2RAB9AL3MBTL1 | |
| SCHEMBL4272450 | 0.72 | RXRA (0.62) | RXRARXRBNR4A2RAB9AL3MBTL1 | |
| SCHEMBL23060136 | 0.72 | MAOB (0.39) | RXRAMAOB | |
| SCHEMBL2452434 | 0.71 | RAB9A (0.59) | RXRARXRBNR4A2RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |