Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6732080 | 0.88 | MEN1 (0.43) | ALDH1A1MAPTTSHRGFERSMN1; SMN2 | |
| SCHEMBL6741613 | 0.85 | SIGMAR1 (0.40) | ALDH1A1MAPTUSP2CYP3A4CYP2D6 | |
| SCHEMBL7719576 | 0.81 | OPRM1 (0.35) | ALDH1A1MAPTKMT2AUSP2CYP3A4 | |
| SCHEMBL6734367 | 0.80 | PKM (0.37) | ALDH1A1MAPTKMT2AUSP2CYP3A4 | |
| SCHEMBL7723935 | 0.80 | ALDH1A1 (0.39) | ALDH1A1MAPTKMT2AMEN1USP2 | |
| SCHEMBL7724992 | 0.79 | ALDH1A1 (0.38) | ALDH1A1MAPTKMT2AMEN1USP2 | |
| Hydrochloric Acid SCHEMBL7725033 | 0.79 | ALDH1A1 (0.38) | ALDH1A1MAPTKMT2AMEN1USP2 | |
| SCHEMBL7724175 | 0.78 | ALDH1A1 (0.38) | ALDH1A1MAPTKMT2AMEN1USP2 | |
| SCHEMBL7214804 | 0.77 | ALDH1A1 (0.42) | ALDH1A1MAPTTSHRSMN1; SMN2KMT2A | |
| SCHEMBL7220076 | 0.77 | ALDH1A1 (0.42) | ALDH1A1MAPTTSHRSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6683200-B2 | N-SUBSTITUTED-N'-SUBSTITUTED UREA DERIVATIVE IS USED AS A TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORY AGENT AND A THERAPEUTICAL AGENT FOR AUTOIMMUNE DISEASES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-01-27 | — | — | US | disclosed |
| US-20020068763-A1 | N-substituted-N'-substituted urea derivatives and pharmaceutical compositions containing the derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-06-06 | — | — | US | disclosed |
| EP-1172358-A1 | N-SUBSTITUTED-N'-SUBSTITUTED UREA DERIVATIVE AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-01-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068763-A1 | N-substituted-N'-substituted urea derivatives and pharmaceutical compositions containing the derivatives | TNF, NFKBIA, UMPS | ALDH1A1 609/4885MAPT 769/4885TSHR 3147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.