Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 9/20 | 0.61 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.49 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.49 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.49 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.44 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1738494 | 1.00 | ADK (0.61) | ADKDOT1LPRMT5PRMT3DNMT1 | |
| SCHEMBL20938191 | 0.89 | ADK (0.67) | ADKDOT1LPRMT5PAX8METTL3 | |
| SCHEMBL10266528 | 0.88 | ADK (0.62) | ADKDOT1LPRMT5PRMT3DNMT1 | |
| SCHEMBL22524105 | 0.85 | ADK (0.54) | ADKDOT1LPRMT5PRMT3DNMT1 | |
| SCHEMBL20938257 | 0.84 | ADK (0.48) | ADKDOT1LPRMT5PAX8METTL3 | |
| SCHEMBL20938256 | 0.84 | ADK (0.48) | ADKDOT1L | |
| SCHEMBL20917719 | 0.84 | ADK (0.48) | ADKDOT1L | |
| SCHEMBL22912603 | 0.84 | PRMT5 (0.48) | ADKDOT1LPRMT5PAX8METTL3 | |
| SCHEMBL20938262 | 0.84 | ADK (0.59) | ADKMETTL3 | |
| SCHEMBL3768787 | 0.84 | ADK (0.61) | ADKDOT1LPRMT5PAX8NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040014957-A1 | Oligonucleotides having modified nucleoside units | ISIS PHARMACEUTICALS, INC. | 2004-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014957-A1 | Oligonucleotides having modified nucleoside units | RNASE1, RNASEH1, RNASEL | ADK 325/4885DOT1L 3215/4885PRMT5 3154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.