Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6742611 | 0.85 | MAPT (0.51) | HPGDMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL2002973 | 0.83 | CYP1A2 (0.44) | HPGDMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL15965560 | 0.81 | HPGD (0.44) | HPGDMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL24091708 | 0.80 | RAB9A (0.49) | HPGDMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL20048220 | 0.80 | HPGD (0.43) | HPGDMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL13204521 | 0.80 | HPGD (0.65) | HPGDMAPTKMT2AALDH1A1NPC1 | |
| SCHEMBL1692271 | 0.80 | HPGD (0.65) | HPGDMAPTKMT2AALDH1A1NPC1 | |
| SCHEMBL19118080 | 0.80 | HPGD (0.65) | HPGDMAPTKMT2AALDH1A1NPC1 | |
| SCHEMBL11938478 | 0.75 | MEN1 (0.70) | HPGDMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL1280508 | 0.73 | SLC6A3 (0.46) | HPGDALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686503-B2 | SPLITITNG FROM SOLID SUPPORT; METHYLATION | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-02-03 | — | — | US | disclosed |
| US-20010041345-A1 | Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries | CHAI WENYING (US) | 2001-11-15 | — | — | US | disclosed |
| US-6288235-B1 | MULTISTAGE REACTION WITH AMIDATION, CLEAVAGE FROM RESIN SUPPORT AND METHYLATION THEN CONDENSATION OF METHYL ESTER TO GIVE 2,4-DIOXOPIPERIDINE COMPOUNDS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010041345-A1 | Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries | DHPS, DRD4, DRD2 | HPGD 1227/4885MAPT 4263/4885MEN1 1915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.