Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | IL1RN | P18510 | 1/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.44 |
| ▸ | PKLR | P30613 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6741834 | 0.86 | KMT2A (0.61) | KEAP1ALDH1A1KMT2AMEN1PKM | |
| SCHEMBL784141 | 0.82 | KEAP1 (0.66) | KEAP1NFE2L2ALDH1A1SNCATDP1 | |
| SCHEMBL7856929 | 0.80 | KEAP1 (0.63) | KEAP1NFE2L2ALDH1A1SNCATDP1 | |
| SCHEMBL2565637 | 0.76 | KEAP1 (0.64) | KEAP1NFE2L2ALDH1A1SNCAKMT2A | |
| SCHEMBL11102014 | 0.75 | ALDH1A1 (0.65) | ALDH1A1PKMALOX15MAPTHPGD | |
| SCHEMBL5015931 | 0.75 | KEAP1 (0.68) | KEAP1NFE2L2ALDH1A1SNCAKMT2A | |
| SCHEMBL30676966 | 0.75 | KEAP1 (0.65) | KEAP1NFE2L2ALDH1A1SNCAKMT2A | |
| SCHEMBL29118864 | 0.75 | KEAP1 (0.65) | KEAP1NFE2L2ALDH1A1SNCAKMT2A | |
| SCHEMBL5330736 | 0.74 | ALDH1A1 (0.64) | KEAP1NFE2L2ALDH1A1SNCATDP1 | |
| SCHEMBL1094118 | 0.73 | MEN1 (0.73) | KEAP1ALDH1A1TDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063783-A1 | Nitroso diphenylamine derivatives | MERCK PATENT GMBH (DE) | 2004-04-01 | — | — | US | disclosed |
| EP-1322598-A1 | NITROSO DIPHENYLAMINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002028820-A1 | NITROSO DIPHENYLAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063783-A1 | Nitroso diphenylamine derivatives | NQO2, SULT1A1, NAT1 | KEAP1 1607/4885NFE2L2 90/4885ALDH1A1 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.