SCHEMBL674004

SCHEMBL674004

CC(CN1CCCNCCNCCCNCC1)N1CCCNCCNCCCNCC1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CXCR4 P61073 13/20 0.50
MEN1 O00255 1/20 0.45
CHRM2 P08172 1/20 0.45
CHRM1 P11229 1/20 0.45
ADRA2C P18825 1/20 0.45
CCR2 P41597 1/20 0.45
CXCL12 P48061 1/20 0.45
BLM P54132 1/20 0.45
KMT2A Q03164 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
HRH3 Q9Y5N1 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.38
CHRM5 P08912 1/20 0.37
CHRM3 P20309 1/20 0.37
PTGS1 P23219 2/20 0.35
LMNA P02545 1/20 0.35
TOP2A P11388 1/20 0.35
TOP2B Q02880 1/20 0.35
SIGMAR1 Q99720 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3966619 0.89 SMN1; SMN2 (0.44) CXCR4MEN1CHRM2CHRM1ADRA2C
SCHEMBL5689073 0.87 SMN1; SMN2 (0.46) CXCR4MEN1CHRM2KMT2ASMN1; SMN2
SCHEMBL11066505 0.85 MEN1 (0.40) CXCR4MEN1CHRM2KMT2AHRH3
SCHEMBL9066655 0.82 SMN1; SMN2 (0.42) CXCR4MEN1KMT2ASMN1; SMN2CHRM5
SCHEMBL673985 0.80 CXCR4 (0.47) CXCR4MEN1CHRM2CHRM1ADRA2C
SCHEMBL28888023 0.79 CXCR4 (0.53) CXCR4MEN1CHRM2CHRM1ADRA2C
SCHEMBL674208 0.78 CXCR4 (0.45) CXCR4MEN1CHRM2CHRM1ADRA2C
SCHEMBL22996225 0.77 CXCR4 (0.50) CXCR4MEN1CHRM2CHRM1ADRA2C
SCHEMBL9829105 0.77 CXCR4 (0.50) CXCR4MEN1CHRM2CHRM1ADRA2C
SCHEMBL2550467 0.77 MEN1 (0.44) MEN1CHRM2ADRA2CKMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210161859-A1 USE OF CXCR4 ANTAGONISTS University of Washington Center for Commercialization 2021-06-03 US claimed
US-20150030561-A1 Use of CXCR4 Antagonists GENZYME CORP. (US) 2015-01-29 US claimed
EP-2709991-A1 USE OF CXCR4 ANTAGONISTS Genzyme Corporation (US) 2014-03-26 EP claimed
WO-2012158707-A1 USE OF CXCR4 ANTAGONISTS GENZYME CORPORATION (US) 2012-11-22 WO claimed
US-20110280827-A1 METHODS AND COMPOSITIONS FOR TREATING HEMATOLOGICAL MALIGNANCIES HU YANPING (US) 2011-11-17 US claimed
US-20110281814-A1 METHODS AND COMPOSITIONS FOR TREATING BREAST CANCER GENZYME CORPORATION 2011-11-17 US claimed
EP-2371361-A1 Methods to mobilize progenitor/stem cells Genzyme Global S.à.r.l. (LU) 2011-10-05 EP claimed
US-7935692-B2 Methods to mobilize progenitor/stem cells GENZYME CORPORATION (US) 2011-05-03 US claimed
US-20100035941-A1 METHODS FOR INCREASING BLOOD FLOW AND/OR PROMOTING TISSUE REGENERATION GENZYME CORPORATION 2010-02-11 US claimed
WO-2007047882-A2 COMBINATION OF CXCR4 ANTAGONIST AND MORPHOGEN TO INCREASE ANGIOGENESIS CARITAS ST. ELIZABETH MEDICAL CENTER OF BOSTON, INC. (US) 2007-04-26 WO claimed
US-20060194776-A1 Compositions and methods for treating tissue ischemia CARITAS ST. ELIZABETH MEDICAL CENTER OF BOSTON, INC. (US) 2006-08-31 US claimed
EP-1148875-B1 METHODS AND COMPOSITIONS TO ENHANCE WHITE BLOOD CELL COUNT ANORMED INC (CA) 2004-06-09 EP claimed
US-6670354-B2 Administering cyclic polyamine compound to elevate white blood cell (WBC) count ANORMED, INC. 2003-12-30 US claimed
US-20020058653-A1 Methods to enhance white blood cell count ANORMED, INC. (CA) 2002-05-16 US claimed
US-6365583-B1 ADMINISTERING NITROGEN CONTAINING CYCLIC COMPOUNDS FOR THERAPY OF ENHANCING WHITE BLOOD CELL COUNT ANORMED, INC. 2002-04-02 US claimed
EP-1148875-A1 METHODS AND COMPOSITIONS TO ENHANCE WHITE BLOOD CELL COUNT ANORMED INC. (CA) 2001-10-31 EP claimed
WO-2000045814-A1 METHODS AND COMPOSITIONS TO ENHANCE WHITE BLOOD CELL COUNT ANORMED INC. (CA) 2000-08-10 WO claimed
US-6001826-A CONTAINING TWO TETRAAZACYCLOHEXADECANE, PENTAAZACYCLOHEAXDECANE, OR TETRAAZACYCLOTETRADECANE RINGS; ACTIVE AGAINST HIV-INFECTED CELLS ANORMED, INC. (CA) 1999-12-14 US claimed
WO-2025230907-A1 A CXCR4 ANTAGONIST, A STATS ACTIVATOR, AND/OR AN AGENT THAT INCREASES NITRIC OXIDE CONTENT FOR USE IN METHODS OF IMPROVING NERVE REGENERATION THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-11-06 WO disclosed
US-5021409-A Antiviral cyclic polyamines JOHNSON MATTHEY PLC (GB) 1991-06-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210161859-A1 USE OF CXCR4 ANTAGONISTS CXCR4, CXCR2, CXCR3 CXCR4 1/4885MEN1 3707/4885CHRM2 1420/4885
US-20100035941-A1 METHODS FOR INCREASING BLOOD FLOW AND/OR PROMOTING TISSUE REGENERATION CCR2, CXCR4, CXCR2 CXCR4 2/4885MEN1 4046/4885CHRM2 600/4885
US-20150030561-A1 Use of CXCR4 Antagonists CXCR4, CXCR2, CXCR3 CXCR4 1/4885MEN1 3707/4885CHRM2 1420/4885
US-20060194776-A1 Compositions and methods for treating tissue ischemia CXCL12, CXCR4, PDGFA CXCR4 2/4885MEN1 3672/4885CHRM2 2302/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.