Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.40 |
| ▸ | WNT3A | P56704 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471049 | 0.92 | HCRTR1 (0.38) | HCRTR1HCRTR2MAPTKDM4ECTNNB1 | |
| SCHEMBL6744208 | 0.81 | GSK3B (0.58) | MAPTKDM4ECTNNB1WNT3AGAA | |
| SCHEMBL23835758 | 0.71 | PGR (0.43) | MAPTKDM4EGAAL3MBTL1GSK3B | |
| SCHEMBL1011575 | 0.70 | KDM4E (0.52) | HCRTR1HCRTR2MAPTKDM4EGAA | |
| SCHEMBL28024995 | 0.67 | KDM1A (0.44) | MAPTKDM4EGAAKDM1AMAOA | |
| SCHEMBL31497405 | 0.66 | GRIN1 (0.48) | MAPTKDM4EGAAKDM1AMAOA | |
| SCHEMBL7810050 | 0.65 | HTR1D (0.54) | HCRTR1HCRTR2MAPTKDM4EKDM1A | |
| SCHEMBL7810045 | 0.65 | HTR1D (0.54) | HCRTR1HCRTR2MAPTKDM4EKDM1A | |
| SCHEMBL7813934 | 0.65 | HTR1D (0.54) | HCRTR1HCRTR2MAPTKDM4EKDM1A | |
| SCHEMBL14584233 | 0.64 | MAPT (0.81) | HCRTR1HCRTR2MAPTKDM4ECTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |