Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6742673 | 0.92 | HCRTR1 (0.43) | HCRTR1HCRTR2KDM4EMAPTCREBBP | |
| SCHEMBL6744208 | 0.74 | GSK3B (0.58) | KDM4EMAPTCTNNB1WNT3AGSK3B | |
| SCHEMBL152281 | 0.70 | CCNB2 (0.54) | KDM4EMAPTCREBBPLMNACHRM2 | |
| SCHEMBL29622074 | 0.70 | CCNB2 (0.54) | KDM4EMAPTCREBBPLMNACHRM2 | |
| SCHEMBL16494733 | 0.66 | JAK2 (0.38) | KDM4EMAPTLMNAMAPK1KCNH2 | |
| SCHEMBL23835758 | 0.65 | PGR (0.43) | KDM4EMAPTCREBBPDRD2DRD4 | |
| SCHEMBL16494830 | 0.65 | JAK2 (0.47) | BACE1GSK3B | |
| SCHEMBL1011575 | 0.64 | KDM4E (0.52) | HCRTR1HCRTR2KDM4EMAPTKDM1A | |
| SCHEMBL28024995 | 0.61 | KDM1A (0.44) | KDM4EMAPTDRD4KDM1AMAOA | |
| SCHEMBL31497405 | 0.61 | GRIN1 (0.48) | KDM4EMAPTCHRM2KDM1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |