Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.34 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6743877 | 0.93 | PTGS2 (0.47) | PTGS2KIF11CASP1 | |
| SCHEMBL6747309 | 0.90 | PTGS2 (0.47) | PTGS2 | |
| SCHEMBL6745090 | 0.89 | PTGS2 (0.35) | PTGS2KIF11CASP1 | |
| SCHEMBL6749852 | 0.89 | PTGS2 (0.50) | PTGS2CASP1 | |
| SCHEMBL6750004 | 0.88 | PTGS2 (0.46) | PTGS2KIF11CASP1 | |
| SCHEMBL6749827 | 0.87 | KIF11 (0.43) | PTGS2KIF11 | |
| SCHEMBL6746753 | 0.87 | PTGS2 (0.45) | PTGS2KIF11CASP1 | |
| SCHEMBL6746211 | 0.86 | PTGS2 (0.50) | PTGS2CASP1 | |
| SCHEMBL6746746 | 0.86 | PTGS2 (0.35) | PTGS2KIF11CASP1 | |
| SCHEMBL6746412 | 0.86 | PTGS2 (0.34) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |