Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6749852 | 0.90 | PTGS2 (0.50) | PTGS2PTGS1CASP1 | |
| SCHEMBL6745050 | 0.89 | PTGS2 (0.42) | PTGS2PTGS1CASP1 | |
| SCHEMBL6743877 | 0.88 | PTGS2 (0.47) | PTGS2PTGS1CASP1 | |
| SCHEMBL6747309 | 0.88 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL6746730 | 0.86 | PTGS2 (0.38) | PTGS2CASP1 | |
| SCHEMBL6746746 | 0.84 | PTGS2 (0.35) | PTGS2PTGS1CASP1 | |
| SCHEMBL6746815 | 0.84 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL6746439 | 0.83 | CASP1 (0.39) | PTGS2PTGS1CASP1 | |
| SCHEMBL6750004 | 0.83 | PTGS2 (0.46) | PTGS2PTGS1CASP1 | |
| SCHEMBL6746358 | 0.82 | KIF11 (0.46) | PTGS2PTGS1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |