Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6745946 | 0.87 | ALOX5AP (0.43) | NR1H2NR1H3AKR1C3AKR1C2ALOX5AP | |
| SCHEMBL6743464 | 0.85 | PTGS2 (0.38) | NR1H2NR1H3PTGS2 | |
| SCHEMBL6746680 | 0.84 | NR1H2 (0.36) | NR1H2NR1H3AKR1C3AKR1C2PTGS2 | |
| SCHEMBL6745201 | 0.84 | ACLY (0.43) | NR1H2NR1H3ALOX5APFEN1PTGS2 | |
| SCHEMBL6747114 | 0.83 | RAB9A (0.40) | NR1H2NR1H3PTGS2KMT2A | |
| SCHEMBL6749677 | 0.83 | NR1H2 (0.36) | NR1H2NR1H3PTGS2 | |
| SCHEMBL6747448 | 0.83 | NR1H2 (0.37) | NR1H2NR1H3MMP2SCN9A | |
| SCHEMBL6749791 | 0.81 | PTGS2 (0.40) | AKR1C3AKR1C2PTGS2ELANEDDR1 | |
| SCHEMBL6745224 | 0.81 | NR1H2 (0.40) | NR1H2NR1H3ALOX5APFEN1PTGS2 | |
| SCHEMBL6743034 | 0.81 | NR1H2 (0.40) | NR1H2NR1H3ALOX5APFEN1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |