Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | SDHB | P21912 | 1/20 | 0.35 |
| ▸ | LOX | P28300 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6743464 | 0.89 | PTGS2 (0.38) | NR1H2NR1H3PTGS2ACLYPTGS1 | |
| SCHEMBL6749846 | 0.87 | PTGS2 (0.36) | NR1H2NR1H3PTGS2ACLYPTGS1 | |
| SCHEMBL6745201 | 0.87 | ACLY (0.43) | NR1H2NR1H3PTGS2ACLY | |
| SCHEMBL6747114 | 0.86 | RAB9A (0.40) | NR1H2NR1H3PTGS2ACLY | |
| SCHEMBL6749677 | 0.86 | NR1H2 (0.36) | NR1H2NR1H3PTGS2ACLYKAT6A | |
| SCHEMBL6743170 | 0.86 | PTGS2 (0.48) | PTGS2ACLYPTGS1 | |
| SCHEMBL6746771 | 0.84 | NR1H2 (0.41) | NR1H2NR1H3PTGS2AKR1C3AKR1C2 | |
| SCHEMBL6743648 | 0.84 | PTGS2 (0.40) | NR1H2NR1H3PTGS2AKR1C3AKR1C2 | |
| SCHEMBL6746854 | 0.84 | PTGS2 (0.49) | NR1H2NR1H3PTGS2PDE3BPDE3A | |
| SCHEMBL6746028 | 0.84 | PTGS2 (0.49) | NR1H2NR1H3PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |