Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PNMT | P11086 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.40 |
| ▸ | TYMS | P04818 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5388614 | 0.87 | ALDH1A1 (0.45) | MEN1MAPTKMT2AALDH1A1PNMT | |
| SCHEMBL983449 | 0.85 | MEN1 (0.51) | MEN1MAPTKMT2AALDH1A1PNMT | |
| SCHEMBL14053324 | 0.82 | MEN1 (0.49) | MEN1MAPTKMT2AALDH1A1PNMT | |
| SCHEMBL1633977 | 0.76 | ADRA2A (0.46) | MEN1MAPTKMT2AALDH1A1PNMT | |
| SCHEMBL29525659 | 0.76 | ADRA2A (0.46) | MEN1MAPTKMT2AALDH1A1PNMT | |
| SCHEMBL13279705 | 0.75 | TDP2 (0.46) | MEN1MAPTKMT2AALDH1A1PNMT | |
| SCHEMBL9483063 | 0.74 | PNMT (0.65) | MEN1MAPTKMT2AALDH1A1PNMT | |
| SCHEMBL30709850 | 0.74 | PNMT (0.65) | MEN1MAPTKMT2AALDH1A1PNMT | |
| SCHEMBL8698600 | 0.73 | CLK1 (0.44) | MEN1MAPTKMT2AALDH1A1PNMT | |
| SCHEMBL4228822 | 0.73 | MEN1 (0.50) | MEN1MAPTKMT2AALDH1A1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040053992-A1 | Methods for producing chiral chromones, chromanes, amino substituted chromanes and intermediates therefor | ELI LILLY AND COMPANY | 2004-03-18 | — | — | US | claimed |
| EP-2702043-A1 | INHIBITORS OF INDUCIBLE FORM OF 6-PHOSPHOFRUCTOSE-2-KINASE | Exelixis, Inc. (US) | 2014-03-05 | — | — | EP | disclosed |
| CN-101535276-B | 2, 4-diaminopyrimidine fused bicyclic derivatives as ALK and c-MET inhibitors | CEPHALON INC | 2013-08-28 | — | — | CN | disclosed |
| WO-2012149528-A1 | INHIBITORS OF INDUCIBLE FORM OF 6-PHOSPHOFRUCTOSE-2-KINASE | EXELIXIS, INC. (US) | 2012-11-01 | — | — | WO | disclosed |
| CN-101535276-A | 2, 4-diaminopyrimidine fused bicyclic derivatives as ALK and c-MET inhibitors | CEPHALON INC (US) | 2009-09-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053992-A1 | Methods for producing chiral chromones, chromanes, amino substituted chromanes and intermediates therefor | NOTUM, FAR1, CYP51A1 | MEN1 3183/4885MAPT 4852/4885KMT2A 3191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.