Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TDP2 | O95551 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.45 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | S100A4 | P26447 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13279705 | 0.86 | TDP2 (0.46) | MEN1KMT2AMAPTTDP2ALDH1A1 | |
| SCHEMBL6747491 | 0.85 | MEN1 (0.50) | MEN1KMT2AMAPTTDP2ALDH1A1 | |
| Valeric Acid SCHEMBL27511706 | 0.83 | CYSLTR2 (0.43) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL4228822 | 0.81 | MEN1 (0.50) | MEN1KMT2AMAPTTDP2ALDH1A1 | |
| SCHEMBL15489040 | 0.81 | PTPRC (0.53) | MEN1KMT2AMAPTTDP2ALDH1A1 | |
| SCHEMBL9484984 | 0.80 | MAPT (0.63) | MEN1KMT2AMAPTTDP2ALDH1A1 | |
| SCHEMBL1308430 | 0.80 | ALDH1A1 (0.60) | MEN1KMT2AMAPTTDP2ALDH1A1 | |
| SCHEMBL16736955 | 0.77 | MEN1 (0.44) | MEN1KMT2AMAPTTDP2ALDH1A1 | |
| SCHEMBL11576199 | 0.77 | MAPT (0.56) | MEN1KMT2AMAPTTDP2ALDH1A1 | |
| SCHEMBL14169575 | 0.77 | KDM1A (0.46) | MEN1KMT2AMAPTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39755-E1 | 3-(1-hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-one a process for the preparation thereof and the use thereof | CLARIANT FRANCE (FR) | 2007-07-31 | — | — | US | claimed |
| CN-1204133-C | 3-(1-hydroxy-amylene)-5-nitro-3H-benzfuran-2-one, its prepn. method and use | CLARIANT FRANCE SA (FR) | 2005-06-01 | — | — | CN | claimed |
| EP-1116719-B1 | 3-(1-Hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-one, a process for the preparation thereof and the use thereof | CLARIANT FRANCE SA (FR) | 2005-04-06 | — | — | EP | claimed |
| US-6515147-B2 | Chemical intermediates for 2-butyl-5-nitrobenzofuran | CLARIANT FRANCE S.A. (FR) | 2003-02-04 | — | — | US | claimed |
| US-20010012900-A1 | 3-(1-hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-one a process for the preparation thereof and the use thereof | CLARIANT (FRANCE) | 2001-08-09 | — | — | US | claimed |
| CN-1306000-A | 3-(1-hydroxy-amylene)-5-nitro-3h-benzfuran-2-one, its prepn. method and use | CLARIANT FRANCE SA (FR) | 2001-08-01 | — | — | CN | claimed |
| EP-1116719-A2 | 3-(1-Hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-one, a process for the preparation thereof and the use thereof | Clariant (France) S.A. (FR) | 2001-07-18 | — | — | EP | claimed |
| US-20170182010-A1 | BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2017-06-29 | — | — | US | disclosed |
| US-9512097-B2 | Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives | LEK PHARMACEUTICALS D.D. (SI) | 2016-12-06 | — | — | US | disclosed |
| US-9512097-B2 | Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives | LEK PHARMACEUTICALS D.D. (SI) | 2016-12-06 | — | — | US | disclosed |
| WO-2012062918-A1 | PROCESS FOR THE PREPARATION OF 3-AROYL-5-AMINOBENZOFURAN DERIVATIVES | LEK PHARMACEUTICALS D.D. (SI) | 2012-05-18 | — | — | WO | disclosed |
| US-20120004213-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2012-01-05 | — | — | US | disclosed |
| US-20110009649-A1 | METHOD FOR PREPARING 2-(n-BUTYL)-5-NITROBENZOFURAN | FINORGA | 2011-01-13 | — | — | US | disclosed |
| CN-1306000-A | 3-(1-hydroxy-amylene)-5-nitro-3h-benzfuran-2-one, its prepn. method and use | CLARIANT FRANCE SA (FR) | 2001-08-01 | — | — | CN | disclosed |
| EP-1116719-A2 | 3-(1-Hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-one, a process for the preparation thereof and the use thereof | Clariant (France) S.A. (FR) | 2001-07-18 | — | — | EP | disclosed |
| EP-1066039-A1 | SUBSTITUTED QUINAZOLINES AND ANALOGS AND THE USE THEREOF | Cocensys, Inc. (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999044612-A1 | SUBSTITUTED QUINAZOLINES AND ANALOGS AND THE USE THEREOF | COCENSYS, INC. (US) | 1999-09-10 | — | — | WO | disclosed |
| EP-0248213-B1 | HYDROXYPHENYL- AND HYDROXYPHENOXYALKANOIC ACID IODOPROPARGYL ESTERS | THE DOW CHEMICAL COMPANY (US) | 1991-10-30 | — | — | EP | disclosed |
| US-4731466-A | FUNGICIDES | THE DOW CHEMICAL COMPANY (US) | 1988-03-15 | — | — | US | disclosed |
| EP-0248213-A2 | Hydroxyphenyl- and hydroxyphenoxyalkanoic acid iodopropargyl esters | THE DOW CHEMICAL COMPANY (US) | 1987-12-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010012900-A1 | 3-(1-hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-one a process for the preparation thereof and the use thereof | CYP2F1, CYP4F11, CYP1B1 | MEN1 1831/4885KMT2A 1913/4885MAPT 221/4885 |
| US-20110009649-A1 | METHOD FOR PREPARING 2-(n-BUTYL)-5-NITROBENZOFURAN | CYP8B1, NISCH, CBR3 | MEN1 4245/4885KMT2A 3066/4885MAPT 4201/4885 |
| US-20120004213-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | SCD, SCD5, FADS2 | MEN1 4883/4885KMT2A 1389/4885MAPT 3595/4885 |
| US-20170182010-A1 | BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS | ASAH1, ASAH2, ACER2 | MEN1 4313/4885KMT2A 2633/4885MAPT 3812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.