Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7177401 | 0.92 | ERCC5 (0.34) | ERCC5FEN1TDP1FLT1FLT4 | |
| SCHEMBL8488611 | 0.81 | ERCC5 (0.59) | ERCC5FEN1TDP1ALDH1A1KDM4E | |
| SCHEMBL29391001 | 0.80 | SLC6A9 (0.41) | KMT2AALDH1A1KDM4EMEN1MAPK1 | |
| SCHEMBL8041947 | 0.80 | THRA (0.32) | MAPTHPGDTHRBNPC1 | |
| SCHEMBL6751338 | 0.80 | SLC6A9 (0.41) | KMT2AALDH1A1KDM4EMEN1MAPK1 | |
| SCHEMBL9073271 | 0.80 | MAPT (0.35) | ERCC5FEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL7554528 | 0.78 | FLT1 (0.43) | ERCC5FEN1FLT1FLT4KDR | |
| SCHEMBL8492085 | 0.77 | F10 (0.41) | ERCC5FEN1FLT1FLT4KDR | |
| SCHEMBL8389663 | 0.76 | SMN1; SMN2 (0.36) | ERCC5FEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6746643 | 0.75 | ERCC5 (0.36) | ERCC5FEN1KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696613-B2 | REACTING NITROHALOBENZENE DERIVATIVE WITH NITROETHANE IN PRESENCE OF A BASE SELECTED FROM THE GROUP CONSISTING OF A HYDROXIDE, A CARBONATE, A HYDRIDE, AN ALKOXIDE OF AN ALKALI OR ALKALINE EARTH METAL, AND GUANIDINE AND SOLVENT | RHONE POULENC AGROCHIMIE (FR) | 2004-02-24 | — | — | US | disclosed |
| US-6525225-B2 | Reacting a nitro-substituted acetophenone with (1) a mercaptan to replace the nitro group with an alkyl- or phenyl-thio group; or (2) nitroethane to replace the acetyl group with a 1-nitroethyl group | RHONE POULENC AGROCHIMIE (FR) | 2003-02-25 | — | — | US | disclosed |
| US-20020062045-A1 | Process for preparing diketone compounds and precursors thereto | PEVERE VIRGINIE (FR) | 2002-05-23 | — | — | US | disclosed |
| EP-0880498-B1 | PROCESS FOR PREPARING DIKETONE COMPOUNDS | AVENTIS CROPSCIENCE SA (FR) | 2001-11-21 | — | — | EP | disclosed |
| US-20010014761-A1 | Process for preparing diketone compounds and precursors thereto | PEVERE VIRGINIE (FR) | 2001-08-16 | — | — | US | disclosed |
| US-6235942-B1 | REACTION OF KETONE WITH CYCLOPROPANECARBOXYLIC ESTER TO FORM DIKETONE | RHONE-POULENC AGROCHIMIE (FR) | 2001-05-22 | — | — | US | disclosed |
| EP-0880498-A2 | PROCESS FOR PREPARING DIKETONE COMPOUNDS | RHONE-POULENC AGROCHIMIE (FR) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028122-A2 | PROCESS FOR PREPARING DIKETONE COMPOUNDS | RHONE-POULENC AGROCHIMIE (FR) | 1997-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010014761-A1 | Process for preparing diketone compounds and precursors thereto | KMO, DHCR7, KHK | ERCC5 2133/4885FEN1 4278/4885TDP1 3949/4885 |
| US-20020062045-A1 | Process for preparing diketone compounds and precursors thereto | KMO, DHCR7, KHK | ERCC5 2133/4885FEN1 4278/4885TDP1 3949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.