Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 3/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.35 |
| ▸ | FEN1 | P39748 | 6/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6747146 | 0.81 | PTGS2 (0.40) | NR1H2NR1H3PTGS2PTGS1PDE3B | |
| SCHEMBL6745201 | 0.80 | ACLY (0.43) | NR1H2NR1H3PTGS2ALOX5APFEN1 | |
| SCHEMBL6744598 | 0.80 | PTGS2 (0.39) | PTGS2PTGS1PDE3BPDE3AALOX5AP | |
| SCHEMBL6744532 | 0.79 | CCR1 (0.35) | NR1H2NR1H3PTGS2ALOX5APFEN1 | |
| SCHEMBL6743170 | 0.79 | PTGS2 (0.48) | PTGS2PTGS1 | |
| SCHEMBL6746680 | 0.79 | NR1H2 (0.36) | NR1H2NR1H3PTGS2PTGS1PDE3B | |
| SCHEMBL6749846 | 0.77 | PTGS2 (0.36) | NR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL6746727 | 0.77 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL6746028 | 0.77 | PTGS2 (0.49) | NR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL6746854 | 0.77 | PTGS2 (0.49) | NR1H2NR1H3PTGS2PTGS1PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |