Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 8/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 7/20 | 0.34 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.34 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.34 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6747283 | 0.81 | PTGS2 (0.41) | PTGS2PTGS1 | |
| SCHEMBL6749801 | 0.80 | NR1H2 (0.37) | PTGS2PTGS1PDE3BPDE3AMKNK1 | |
| SCHEMBL6745120 | 0.79 | ACLY (0.35) | PTGS2PTGS1CASP1 | |
| SCHEMBL6746753 | 0.78 | PTGS2 (0.45) | PTGS2PTGS1CASP1 | |
| SCHEMBL6746288 | 0.78 | CASP1 (0.35) | PTGS2CASP1 | |
| SCHEMBL6745114 | 0.77 | SDHB (0.38) | PTGS2PTGS1PDE3BPDE3ACASP1 | |
| SCHEMBL6746730 | 0.77 | PTGS2 (0.38) | PTGS2CASP1 | |
| SCHEMBL6744935 | 0.76 | PTGS2 (0.36) | PTGS2PTGS1CASP1 | |
| SCHEMBL6743712 | 0.76 | PTGS2 (0.44) | PTGS2PTGS1CYP2C19 | |
| SCHEMBL6750004 | 0.76 | PTGS2 (0.46) | PTGS2PTGS1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |