Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.31 |
| ▸ | FEN1 | P39748 | 2/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
| ▸ | SIK1 | P57059 | 1/20 | 0.30 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.30 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6749801 | 0.79 | NR1H2 (0.37) | PTGS2NR1H2NR1H3GPR119ALOX5AP | |
| SCHEMBL6746127 | 0.79 | HTT (0.34) | PTGS2GPR119 | |
| SCHEMBL6746680 | 0.78 | NR1H2 (0.36) | PTGS2NR1H2NR1H3 | |
| SCHEMBL6747157 | 0.78 | TGFBR1 (0.37) | CCR1CCR8PTGS2TGFBR1THRB | |
| SCHEMBL6745201 | 0.77 | ACLY (0.43) | PTGS2NR1H2NR1H3ALOX5APFEN1 | |
| SCHEMBL6743464 | 0.77 | PTGS2 (0.38) | PTGS2NR1H2NR1H3 | |
| SCHEMBL6746763 | 0.76 | NR1H2 (0.31) | NR1H2NR1H3 | |
| SCHEMBL6743170 | 0.76 | PTGS2 (0.48) | PTGS2 | |
| SCHEMBL6732406 | 0.76 | CCR1 (0.33) | CCR1CCR8PTGS2TGFBR1NR1H2 | |
| SCHEMBL6735985 | 0.75 | CYP2A6 (0.41) | CCR1CCR8PTGS2TGFBR1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |