Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | IL1RN | P18510 | 1/20 | 0.45 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27464511 | 0.82 | KEAP1 (0.46) | KEAP1CA1CA2KMT2AMEN1 | |
| SCHEMBL28876271 | 0.79 | KEAP1 (0.47) | KEAP1CA1CA2KMT2AMEN1 | |
| SCHEMBL27509690 | 0.79 | LMNA (0.58) | KMT2AMEN1ALDH1A1LMNAGAA | |
| SCHEMBL9136815 | 0.79 | NPC1 (0.49) | CA1CA2CA12CA9HPGD | |
| SCHEMBL28657038 | 0.78 | CA1 (0.55) | KEAP1CA1CA2KMT2AMEN1 | |
| SCHEMBL11868146 | 0.77 | KEAP1 (0.47) | KEAP1CA1CA2KMT2AMEN1 | |
| SCHEMBL30797878 | 0.77 | CA2 (0.44) | KEAP1CA1CA2KMT2AMEN1 | |
| SCHEMBL675949 | 0.77 | KEAP1 (0.58) | KEAP1CA1CA2KMT2AMEN1 | |
| SCHEMBL2016598 | 0.76 | KEAP1 (0.56) | KEAP1CA1CA2KMT2AMEN1 | |
| SCHEMBL5130306 | 0.76 | CA2 (0.42) | KEAP1CA1CA2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11254702-B2 | Thionyl tetrafluoride modified compounds and uses | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-02-22 | — | — | US | disclosed |
| EP-3548465-A1 | THIONYL TETRAFLUORIDE MODIFIED COMPOUNDS AND USES | The Scripps Research Institute (US) | 2019-10-09 | — | — | EP | disclosed |
| US-20190284226-A1 | THIONYL TETRAFLUORIDE MODIFIED COMPOUNDS AND USES | THE SCRIPPS RESEARCH INSTITUTE | 2019-09-19 | — | — | US | disclosed |
| CN-109925312-A | For treating the composition, preparation and method of eye disease | 爱尔皮奥治疗有限公司 | 2019-06-25 | — | — | CN | disclosed |
| CN-105307498-B | Compositions, formulations and methods for treating ocular diseases | 爱尔皮奥治疗有限公司 | 2019-04-16 | — | — | CN | disclosed |
| WO-2018102433-A1 | THIONYL TETRAFLUORIDE MODIFIED COMPOUNDS AND USES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-06-07 | — | — | WO | disclosed |
| US-7968009-B2 | Electrically conductive nanocomposite particles having a polyalkyl acrylate core and a polyaniline coating | UPPA-UNIVERSITE DE PAU ET DES PAYS DE L'ADOUR (FR) | 2011-06-28 | — | — | US | disclosed |
| US-20090212263-A1 | ELECTRICALLY CONDUCTIVE NANOCOMPOSITE PARTICLES HAVING A POLYALKYL ACRYLATE CORE AND A POLYANILINE COATING | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190284226-A1 | THIONYL TETRAFLUORIDE MODIFIED COMPOUNDS AND USES | SFXN3, TST, SIRT3 | KEAP1 1520/4885CA1 3383/4885CA2 3513/4885 |
| US-11254702-B2 | Thionyl tetrafluoride modified compounds and uses | SFXN3, TST, SIRT3 | KEAP1 1520/4885CA1 3383/4885CA2 3513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.