Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | BUB1 | O43683 | 1/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17901900 | 0.97 | HDAC1 (0.56) | HDAC1HDAC6KDM4ERAB9AALDH1A1 | |
| SCHEMBL30480036 | 0.82 | HDAC1 (0.70) | HDAC1HDAC6KDM4ECA1CA2 | |
| SCHEMBL6925178 | 0.82 | HDAC1 (0.70) | HDAC1HDAC6KDM4ECA1CA2 | |
| SCHEMBL7547764 | 0.81 | HDAC1 (0.69) | HDAC1HDAC6KDM4ECA1CA2 | |
| SCHEMBL14487450 | 0.81 | KDM4E (0.68) | HDAC1HDAC6KDM4EALDH1A1ALB | |
| SCHEMBL7547761 | 0.80 | HDAC1 (0.67) | HDAC1HDAC6KDM4ECA1CA2 | |
| SCHEMBL5794392 | 0.80 | ALDH1A1 (0.66) | HDAC1HDAC6KDM4EALDH1A1MAPK1 | |
| SCHEMBL14484494 | 0.80 | HDAC1 (0.57) | HDAC1HDAC6KDM4EALDH1A1BUB1 | |
| SCHEMBL30223533 | 0.80 | HTR2A (0.51) | HDAC1HDAC6KDM4EALDH1A1BUB1 | |
| SCHEMBL1146660 | 0.80 | HTR2A (0.51) | HDAC1HDAC6KDM4EALDH1A1BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230012449-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. | 2023-01-12 | — | — | US | disclosed |
| US-11034668-B2 | Compounds for the treatment of HIV | GILEAD SCIENCES, INC. (US) | 2021-06-15 | — | — | US | disclosed |
| US-10370358-B2 | Compounds for the treatment of HIV | GILEAD SCIENCES, INC. (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180194746-A1 | Compounds For the Treatment of HIV | GILEAD SCIENCES, INC. | 2018-07-12 | — | — | US | disclosed |
| US-20070197580-A1 | Novel 5-HT3 Receptor Antagonists and Methods of Use | MPM ASSET MANAGEMENT INVESTORS 2002 BVIII LLC | 2007-08-23 | — | — | US | disclosed |
| US-6713473-B1 | 6-CARBAMATE-1,2,3,4-TETRAHYDROCARBAZOLE DERIVATIVES; AFFINITY FOR NEUROPEPTIDE Y RECEPTORS | MEIJI SEIKA KAISHA, LTD. (JP) | 2004-03-30 | — | — | US | disclosed |
| EP-1184373-A1 | TRICYCLIC COMPOUNDS | MEIJI SEIKA KAISHA LTD. (JP) | 2002-03-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370358-B2 | Compounds for the treatment of HIV | CCR5, NPC1, FURIN | HDAC1 274/4885HDAC6 872/4885KDM4E 1590/4885 |
| US-20180194746-A1 | Compounds For the Treatment of HIV | CCR5, NPC1, FURIN | HDAC1 274/4885HDAC6 872/4885KDM4E 1590/4885 |
| US-20070197580-A1 | Novel 5-HT3 Receptor Antagonists and Methods of Use | HTR5A, HTR3A, HTR3B | HDAC1 3685/4885HDAC6 1772/4885KDM4E 2618/4885 |
| US-11034668-B2 | Compounds for the treatment of HIV | CCR5, NPC1, FURIN | HDAC1 274/4885HDAC6 872/4885KDM4E 1590/4885 |
| US-20230012449-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | CCR5, NPC1, FURIN | HDAC1 274/4885HDAC6 872/4885KDM4E 1590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.