Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Creatine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 18/20 | 0.41 |
| ▸ | CA2 | P00918 | 18/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Creatine SCHEMBL3807770 | 0.95 | CA1 (0.41) | CA1CA2NOS3NOS1NOS2 | |
| Creatine SCHEMBL5569335 | 0.95 | CA1 (0.41) | CA1CA2NOS3NOS1NOS2 | |
| Creatine SCHEMBL3816605 | 0.95 | CA1 (0.41) | CA1CA2NOS3NOS1NOS2 | |
| Creatine SCHEMBL6673726 | 0.95 | CA1 (0.41) | CA1CA2NOS3NOS1NOS2 | |
| Creatine SCHEMBL7858043 | 0.95 | CA1 (0.41) | CA1CA2NOS3NOS1NOS2 | |
| Creatine SCHEMBL4269044 | 0.95 | CA1 (0.41) | CA1CA2NOS3NOS1NOS2 | |
| Creatine SCHEMBL4885845 | 0.95 | CA1 (0.41) | CA1CA2NOS3NOS1NOS2 | |
| Creatine SCHEMBL9391271 | 0.93 | CA1 (0.41) | CA1CA2NOS3NOS1NOS2 | |
| Creatine SCHEMBL1065566 | 0.88 | NOS3 (0.39) | CA1CA2NOS3NOS1NOS2 | |
| Creatine SCHEMBL9568829 | 0.88 | NOS3 (0.39) | CA1CA2NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 264 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240138438-A1 | CREATINE NUTRITIONAL SUPPLEMENT | MENTER DYLAN (US) | 2024-05-02 | — | — | US | claimed |
| US-11865097-B2 | Creatine nutritional supplement | MENTER DYLAN (US) | 2024-01-09 | — | — | US | claimed |
| CN-116606226-A | Creatine magnesium and preparation method thereof | 天津天鼎仁科技有限公司 | 2023-08-18 | — | — | CN | claimed |
| US-20230233499-A1 | CREATINE NUTRITIONAL SUPPLEMENT | MENTER DYLAN (US) | 2023-07-27 | — | — | US | claimed |
| US-11690858-B1 | Neuroprotective mixture for mitigating the harmful effects of ischemic stroke | TRICERAPRO HOLDING, LLC (US) | 2023-07-04 | — | — | US | claimed |
| US-11642327-B2 | Creatine nutritional supplement | MENTER DYLAN ROBERT (US) | 2023-05-09 | — | — | US | claimed |
| US-20230108723-A1 | Multi-Nutrient Composition | EXERKINE CORPORATION (CA) | 2023-04-06 | — | — | US | claimed |
| US-11534458-B2 | Phosphorus-sparing nutritional composition | ALBION LABORATORIES, INC. (US) | 2022-12-27 | — | — | US | claimed |
| US-11504413-B2 | Multi-nutrient composition | EXERKINE CORPORATION (CA) | 2022-11-22 | — | — | US | claimed |
| US-20220054442-A1 | Creatine Nutritional Supplement | MENTER DYLAN (US) | 2022-02-24 | — | — | US | claimed |
| US-20080089962-A1 | NUTRITIONAL COMPOSITION FOR FACILITATING MUSCLE PUMPS | MULTI FORMULATIONS LTD. (CA) | 2008-04-17 | — | — | US | claimed |
| US-20080063689-A1 | Dietary supplements containing anthocyanins and methods for using same to enhance creatine absorption and vasodilation | FARBER MIKE | 2008-03-13 | — | — | US | claimed |
| EP-1755401-A1 | DIETARY SUPPLEMENTS CONTAINING EXTRACTS OF CINNAMON AND METHODS OF USING SAME TO ENHANCE CREATINE TRANSPORT | MILLER, Peter (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005099455-A1 | DIETARY SUPPLEMENTS CONTAINING EXTRACTS OF CINNAMON AND METHODS OF USING SAME TO ENHANCE CREATINE TRANSPORT | MILLER PETER (US) | 2005-10-27 | — | — | WO | claimed |
| US-6903136-B2 | Food supplements containing 4-hydroxyisoleucine and creatine | EXPERIMENTAL AND APPLIED SCIENCES, INC. (US) | 2005-06-07 | — | — | US | claimed |
| US-20040224035-A1 | Dietary supplements containing extracts of cinnamon and methods of using same to enhance creatine transport | IN INGREDIENTS, INC. | 2004-11-11 | — | — | US | claimed |
| US-20040043013-A1 | Metabolic uncoupling therapy | MCCLEARY EDWARD LARRY (US) | 2004-03-04 | — | — | US | claimed |
| US-20030224062-A1 | Food supplements containing 4-hydroxyisoleucine and creatine | NATIONAL SUPPLEMENT ASSOCIATION, INCORPORATED | 2003-12-04 | — | — | US | claimed |
| WO-2003088947-A1 | FOOD SUPPLEMENTS CONTAINING 4-HYDROXYISOLEUCINE AND CREATINE | EXPERIMENTAL & APPLIED SCIENCES, INC. (US) | 2003-10-30 | — | — | WO | claimed |
| US-6465018-B1 | BLEND OF CREATINE, GINSENG, AND ASTRAGALUS, AND, OPTIONALLY, GLUTAMINE | TUTTLE B DAVID (US) | 2002-10-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080089962-A1 | NUTRITIONAL COMPOSITION FOR FACILITATING MUSCLE PUMPS | MUSK, BCAT1, PYGM | CA1 3157/4885CA2 791/4885NOS3 44/4885 |
| US-11534458-B2 | Phosphorus-sparing nutritional composition | PHPT1, PPA1, PTH1R | CA1 324/4885CA2 72/4885NOS3 2704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.