Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.40 |
| ▸ | TUBB | P07437 | 2/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.40 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21050025 | 0.83 | CYP1A2 (0.48) | RAF1CYP1A2CDK1CYP2C9CCNB1 | |
| SCHEMBL66212 | 0.83 | KDM4E (0.50) | RAF1CYP1A2CDK1CYP2C9CCNB1 | |
| SCHEMBL80769 | 0.78 | RAF1 (0.43) | RAF1CYP1A2CDK1CYP2C9CCNB1 | |
| SCHEMBL21276637 | 0.74 | RAF1 (0.38) | RAF1CYP1A2CDK1CYP2C9CCNB1 | |
| SCHEMBL632905 | 0.73 | — | — | |
| SCHEMBL25046297 | 0.71 | KDM4E (0.50) | RAF1CYP1A2CDK1CYP2C9CCNB1 | |
| SCHEMBL1509437 | 0.70 | — | — | |
| SCHEMBL12244444 | 0.70 | HPGD (0.36) | RAF1CYP1A2CDK1CYP2C9CCNB1 | |
| SCHEMBL21718551 | 0.68 | TUBB4A (0.39) | RAF1CYP1A2CDK1CYP2C9CCNB1 | |
| SCHEMBL21719515 | 0.68 | CDK2 (0.35) | RAF1CYP1A2CDK1CYP2C9CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4089085-B1 | MANUFACTURING AND PURIFICATION METHOD OF POLYCRYSTALLINE FORM OF DEHYDROPHENYLAHISTIN-LIKE COMPOUND | SHENZHEN HUAHONG MARINE BIOMEDICINE CO LTD (CN) | 2024-04-03 | — | — | EP | claimed |
| US-11608325-B2 | Polycrystalline form of dehydrophenylahistin-like compound, and manufacturing and purification method and application thereof | Shenzhen Huahong Marine Biomedicine Co., Ltd. (CN) | 2023-03-21 | — | — | US | claimed |
| EP-4089085-A1 | MANUFACTURING AND PURIFICATION METHOD OF POLYCRYSTALLINE FORM OF DEHYDROPHENYLAHISTIN-LIKE COMPOUND | Shenzhen BGI Marine Sci & Tech Co., Ltd (CN) | 2022-11-16 | — | — | EP | claimed |
| CN-109580801-A | A kind of high performance liquid chromatography detecting Antitubulin and related impurities | 深圳海王医药科技研究院有限公司 | 2019-04-05 | — | — | CN | claimed |
| CN-119330935-A | Salt of plinabulin and use thereof | 成都施贝康生物医药科技有限公司 | 2025-01-21 | — | — | CN | disclosed |
| EP-4089085-B1 | MANUFACTURING AND PURIFICATION METHOD OF POLYCRYSTALLINE FORM OF DEHYDROPHENYLAHISTIN-LIKE COMPOUND | SHENZHEN HUAHONG MARINE BIOMEDICINE CO LTD (CN) | 2024-04-03 | — | — | EP | disclosed |
| CN-117510476-A | Plinabulin derivative, preparation method and application thereof | 中国科学院长春应用化学研究所 | 2024-02-06 | — | — | CN | disclosed |
| CN-117285516-A | Dehydrogenated phenyl achyranthis statin compound, preparation method and application thereof | 大连万众益生大健康有限公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-114276332-B | Polymorphic form of dehydrogenated phenyl-achyranthes and its preparing and purifying process and application | 深圳华大海洋科技有限公司 | 2023-08-18 | — | — | CN | disclosed |
| CN-116496257-A | Pranabulin prodrug, preparation method and application thereof | 成都施贝康生物医药科技有限公司 | 2023-07-28 | — | — | CN | disclosed |
| US-11608325-B2 | Polycrystalline form of dehydrophenylahistin-like compound, and manufacturing and purification method and application thereof | Shenzhen Huahong Marine Biomedicine Co., Ltd. (CN) | 2023-03-21 | — | — | US | disclosed |
| US-11578057-B2 | Polycrystalline form of dehydrophenylahistin-like compound, and manufacturing and purification method and application thereof | Shenzhen Huahong Marine Biomedicine Co., Ltd. (CN) | 2023-02-14 | — | — | US | disclosed |
| US-20060217553-A1 | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof | NEREUS PHARMACEUTICALS, INC. | 2006-09-28 | — | — | US | disclosed |
| US-7064201-B2 | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof | NEREUS PHARMACEUTICALS, INC. (US) | 2006-06-20 | — | — | US | disclosed |
| CN-1684955-A | Dehydrophenylahistine and analogs thereof and synthesis of dehydrophenylahistine and analogs thereof | NEREUS PHARMACEUTICALS INC (US) | 2005-10-19 | — | — | CN | disclosed |
| US-20050197344-A1 | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof | BEYONDSPRING PHARMACEUTICALS, INC. | 2005-09-08 | — | — | US | disclosed |
| WO-2005077940-A1 | DEHYDROPHENYLAHISTINS AND ANALOGS THEREOF AND THE SYNTHESIS OF DEHYDROPHENYLAHISTINS AND ANALOGS THEREOF | NEREUS PHARMACEUTICALS, INC. (US) | 2005-08-25 | — | — | WO | disclosed |
| EP-1529044-A2 | DEHYDROPHENYLAHISTINS AND ANALOGS THEREOF AND THE SYNTHESIS OF DEHYDROPHENYLAHISTINS AND ANALOGS THEREOF | Nereus Pharmaceuticals, Inc. (US) | 2005-05-11 | — | — | EP | disclosed |
| US-20050090667-A1 | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof | BEYONDSPRING PHARMACEUTICALS, INC. | 2005-04-28 | — | — | US | disclosed |
| WO-2004054498-A2 | DEHYDROPHENYLAHISTINS AND ANALOGS THEREOF AND THE SYNTHESIS OF DEHYDROPHENYLAHISTINS AND ANALOGS THEREOF | NEREUS PHARMACEUTICALS, INC. (US) | 2004-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060217553-A1 | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof | TPD52L2, DHPS, DCXR | RAF1 2336/4885CYP1A2 464/4885CDK1 465/4885 |
| US-20050090667-A1 | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof | TPD52L2, DHPS, DCXR | RAF1 2336/4885CYP1A2 464/4885CDK1 465/4885 |
| US-11608325-B2 | Polycrystalline form of dehydrophenylahistin-like compound, and manufacturing and purification method and application thereof | DHPS, HDHD5, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | RAF1 1372/4885CYP1A2 1849/4885CDK1 2739/4885 |
| US-20050197344-A1 | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof | DHFR, DHPS, QDPR | RAF1 2807/4885CYP1A2 951/4885CDK1 418/4885 |
| US-11578057-B2 | Polycrystalline form of dehydrophenylahistin-like compound, and manufacturing and purification method and application thereof | DHPS, HDHD5, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | RAF1 1463/4885CYP1A2 1798/4885CDK1 2651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.