SCHEMBL676043

SCHEMBL676043

O=C(CCCCN1CCOCC1)Nc1ccc(-c2cccnc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 2/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29447952 1.00 CHRNA7 (0.80) CHRNA7
Hydrochloric Acid SCHEMBL15663070 0.99 CHRNA7 (0.79) CHRNA7
SCHEMBL14006127 0.90 CHRNA7 (0.98) CHRNA7
SCHEMBL14005997 0.89 CHRNA7 (1.00) CHRNA7
SCHEMBL14005985 0.88 CHRNA7 (0.82) CHRNA7
SCHEMBL14006077 0.85 CHRNA7 (0.81) CHRNA7
SCHEMBL14005980 0.85 CHRNA7 (0.77) CHRNA7
SCHEMBL14006109 0.82 KDR (0.61)
SCHEMBL23540740 0.79 LMNA (0.71)
SCHEMBL30043036 0.79 LMNA (0.71)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230102192-A1 THERAPIES FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH ABNORMAL EXPRESSION OF A NEURAL-ASSOCIATED GENE UNIV CALIFORNIA (US) 2023-03-30 US claimed
EP-3284467-B1 NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITIONS NICONOVUM USA INC (US) 2019-10-30 EP claimed
EP-3328383-A1 ANTITUSSIVE COMPOSITIONS AND METHODS Attenua, Inc. (US) 2018-06-06 EP claimed
EP-2566476-B1 NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITIONS NICONOVUM USA INC (US) 2017-11-22 EP claimed
US-20170273957-A1 ANTITUSSIVE COMPOSITIONS AND METHODS ATTENUA, INC. 2017-09-28 US claimed
WO-2017023700-A1 ANTITUSSIVE COMPOSITIONS AND METHODS ATTENUA, INC. (US) 2017-02-09 WO claimed
US-20110274628-A1 NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITIONS NICONOVUM USA, INC. 2011-11-10 US claimed
WO-2011139811-A1 NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITIONS NICONOVUM USA, INC. (US) 2011-11-10 WO claimed
US-20260137689-A1 INTEGRATION OF MOLECULAR MECHANISMS IN THE STRIATUM AS A COMBINATION DRUG STRATEGY FOR THE TREATMENT OF PSYCHIATRIC AND NEUROLOGICAL DISORDERS IN WHICH ANHEDONIA OR MOTIVATION-RELATED DYSFUNCTION EXISTS ALTO NEUROSCIENCE INC (US) 2026-05-21 US disclosed
US-20250295611-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS TESSELLATE THERAPEUTICS INC (US) 2025-09-25 US disclosed
US-12215387-B2 Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment NOVARTIS AG (CH) 2025-02-04 US disclosed
EP-4281065-A1 ENHANCEMENT OF CAMP SIGNALING AS A COMBINATION DRUG STRATEGY FOR THE TREATMENT OF DEPRESSION AND RELATED CONDITIONS Alto Neuroscience, Inc. (US) 2023-11-29 EP disclosed
EP-4281056-A1 COMBINATION DRUG STRATEGY FOR THE TREATMENT OF PSYCHIATRIC AND NEUROLOGICAL DISORDERS IN WHICH ANHEDONIA OR MOTIVATION- RELATED DYSFUNCTION EXISTS Alto Neuroscience, Inc. (US) 2023-11-29 EP disclosed
WO-2023212244-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS TESSELLATE THERAPEUTICS, INC. (US) 2023-11-02 WO disclosed
WO-2013002365-A1 ANTIPRURITIC AGENT 東レ株式会社 (JP) 2013-01-03 WO disclosed
US-20110274628-A1 NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITIONS NICONOVUM USA, INC. 2011-11-10 US disclosed
WO-2011139811-A1 NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITIONS NICONOVUM USA, INC. (US) 2011-11-10 WO disclosed
WO-2011036167-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG (CH) 2011-03-31 WO disclosed
US-20080275028-A1 Modulators or Alpha7 Nicotinic Acetylcholine Receptors and Therapeutic Uses Thereof SIENA BIOTECH S.P.A. (IT) 2008-11-06 US disclosed
US-20080275028-A1 Modulators or Alpha7 Nicotinic Acetylcholine Receptors and Therapeutic Uses Thereof SIENA BIOTECH S.P.A. (IT) 2008-11-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260137689-A1 INTEGRATION OF MOLECULAR MECHANISMS IN THE STRIATUM AS A COMBINATION DRUG STRATEGY FOR THE TREATMENT OF PSYCHIATRIC AND NEUROLOGICAL DISORDERS IN WHICH ANHEDONIA OR MOTIVATION-RELATED DYSFUNCTION EXISTS CHRNA5, CHRNA2, CHRNA4 CHRNA7 4/4885
US-20170273957-A1 ANTITUSSIVE COMPOSITIONS AND METHODS CHRNA7, CHRNA1, CHRNG CHRNA7 1/4885
US-20230102192-A1 THERAPIES FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH ABNORMAL EXPRESSION OF A NEURAL-ASSOCIATED GENE CHRNA7, CHRNA3, CHRNA6 CHRNA7 1/4885
US-12215387-B2 Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment CHRNA7, CHRNA4, CHRNA5 CHRNA7 1/4885
US-20250295611-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS HTR2A, HTR5A, HTR6 CHRNA7 83/4885
US-20080275028-A1 Modulators or Alpha7 Nicotinic Acetylcholine Receptors and Therapeutic Uses Thereof CHRNA7, CHRNA5, CHRNA1 CHRNA7 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.