SCHEMBL6761561

SCHEMBL6761561

O=C(CCOc1ccc(Cl)cc1)NNS(=O)(=O)c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ KAT6A Q92794 7/20 0.53
▸ HTR1A P08908 1/20 0.51
▸ HTR7 P34969 1/20 0.51
▸ GAA P10253 1/20 0.50
▸ AR P10275 1/20 0.49
▸ HTT P42858 1/20 0.49
▸ EGFR P00533 1/20 0.48
▸ ERBB2 P04626 1/20 0.48
▸ MEN1 O00255 1/20 0.47
▸ LMNA P02545 1/20 0.47
▸ MAPT P10636 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ MMP3 P08254 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6769551 0.93 GAA (0.51) KAT6AGAAAREGFRERBB2
SCHEMBL6764958 0.83 KAT6A (0.52) KAT6AGAALMNAKMT2A
SCHEMBL6764909 0.83 RAB9A (0.57) GAAHTTMEN1MAPTKMT2A
SCHEMBL6769558 0.81 KMT2A (0.50) GAAMEN1LMNAKMT2A
SCHEMBL7109395 0.78 RAB9A (0.56) GAAMEN1LMNAMAPTKMT2A
SCHEMBL20233293 0.75 KAT6A (0.78) KAT6AGAAHTTMEN1KMT2A
SCHEMBL15482049 0.74 CYP2C19 (0.59) KAT6AGAAHTTMEN1LMNA
SCHEMBL6761507 0.71 ALDH1A1 (0.51) HTTMEN1LMNAMAPTKMT2A
SCHEMBL355627 0.70 L3MBTL1 (0.67) HTTMEN1LMNAKMT2A
SCHEMBL5794551 0.70 ALDH1A1 (0.51) GAAHTTEGFRERBB2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6730704-B2 REACTING AN ARYLOXYPROPIONIC ACID HYDRAZIDE WITH AN ARYLSULFONYL CHLORIDE COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2004-05-04 — — US disclosed
US-20030187065-A1 1-(ARYLOXY)PROPIONOYL-2-ARYLSULFONYL HYDRAZINES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS HYPOGLYCEMIC AGENTS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH 2003-10-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030187065-A1 1-(ARYLOXY)PROPIONOYL-2-ARYLSULFONYL HYDRAZINES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS HYPOGLYCEMIC AGENTS IAPP, DPP4, GLP1R KAT6A 4223/4885HTR1A 2441/4885HTR7 1670/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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