SCHEMBL6761682

SCHEMBL6761682

Cc1c(Cl)ccc(S(=O)(=O)NCCc2cccnc2)c1Cl

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PKM P14618 2/20 0.61
PRMT5 O14744 1/20 0.50
WDR77 Q9BQA1 1/20 0.50
TBXAS1 P24557 5/20 0.48
POLB P06746 2/20 0.47
TSHR P16473 2/20 0.46
CSNK1A1 P48729 1/20 0.44
CSNK1D P48730 1/20 0.44
CSNK1E P49674 1/20 0.44
CSNK1G2 P78368 1/20 0.44
CSNK1G1 Q9HCP0 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4029240 0.85 ALDH1A1 (0.54) POLBCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL4618242 0.75 SFRP1 (0.58) PKMTBXAS1
SCHEMBL10836333 0.75 TBXAS1 (0.71) TBXAS1
SCHEMBL7670526 0.73 CHRNA7 (0.49) PKMTBXAS1CYP1A2CYP3A4CYP2C9
SCHEMBL27713238 0.72 TDP1 (0.70) TBXAS1
SCHEMBL7423225 0.72 KDM4E (0.56) TBXAS1
Hydrochloric Acid SCHEMBL1238218 0.71 TDP1 (0.68) TBXAS1
SCHEMBL1236774 0.70 ALDH1A1 (0.76) TBXAS1
SCHEMBL22467392 0.70 EDNRB (0.41) PKMPRMT5WDR77POLBCYP3A4
SCHEMBL4030663 0.69 WDR5 (0.46) POLBCSNK1A1CSNK1DCSNK1ECSNK1G2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040063725-A1 Novel n(phenylsulphonyl)glycine derivatives and their therapeutic use LABORATORIES FOURNIER S.A. (FR) 2004-04-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040063725-A1 Novel n(phenylsulphonyl)glycine derivatives and their therapeutic use GLS, GLS2, GLRB PKM 1700/4885PRMT5 879/4885WDR77 2911/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.