Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.64 |
| ▸ | HTR1D | P28221 | 8/20 | 0.64 |
| ▸ | HTR1B | P28222 | 7/20 | 0.64 |
| ▸ | HTR7 | P34969 | 4/20 | 0.64 |
| ▸ | HTR2C | P28335 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.64 |
| ▸ | HTR5A | P47898 | 3/20 | 0.64 |
| ▸ | HTR6 | P50406 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 6/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | HTR1E | P28566 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.58 |
| ▸ | HTR3B | O95264 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9258576 | 0.91 | MPO (0.58) | HTR1AHTR1DHTR1BHTR7HTR2C | |
| SCHEMBL6153313 | 0.89 | HTR7 (0.64) | HTR1AHTR1DHTR1BHTR7HTR2C | |
| SCHEMBL10552982 | 0.88 | HTR1D (0.69) | HTR1AHTR1DHTR1BHTR7HTR2C | |
| SCHEMBL10555088 | 0.86 | HTR1A (0.58) | HTR1AHTR1DHTR1BHTR7HTR2C | |
| SCHEMBL10552426 | 0.85 | HTR1D (0.62) | HTR1AHTR1DHTR1BHTR7HTR2C | |
| SCHEMBL10578720 | 0.85 | HTR1D (0.62) | HTR1AHTR1DHTR1BHTR7HTR2C | |
| SCHEMBL10577690 | 0.84 | HTR1D (0.61) | HTR1AHTR1DHTR1BHTR7HTR2C | |
| SCHEMBL10555975 | 0.84 | HTR1A (0.57) | HTR1AHTR1DHTR1BHTR7HTR2C | |
| Water SCHEMBL10579379 | 0.84 | KDM4E (0.60) | HTR1AHTR1DHTR1BHTR2CCYP1A2 | |
| SCHEMBL10576242 | 0.84 | HTR1A (0.60) | HTR1AHTR1DHTR1BHTR7HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4803218-A | HYPOTENSIVE AGENTS | MCNEILAB, INC. (US) | 1989-02-07 | — | — | US | claimed |
| US-20040198803-A1 | Such as 5-(methoxycarbonylamino)-N - acetyltryptamine; therapy for ocular hypertension; vision defects | PINTOR JESUS J (ES) | 2004-10-07 | — | — | US | disclosed |
| US-6730707-B2 | SUCH AS 5-(METHOXYCARBONYLAMINO)-N-ACETYLTRYPTAMINE; TREATING OCULAR HYPERTENSION, VARIOUS FORMS OF GLAUCOMA | INSPIRE PHARMACEUTICALS, INC. | 2004-05-04 | — | — | US | disclosed |
| EP-1307191-A2 | USE OF INDOLE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR REDUCING INTRACULAR PRESSURE | Inspire Pharmaceuticals, Inc. (US) | 2003-05-07 | — | — | EP | disclosed |
| US-20020037887-A1 | Method for reducing intraocular pressure using indole derivatives | UNIVERSIDAD COMPLUTENSE DE MADRID (ES) | 2002-03-28 | — | — | US | disclosed |
| WO-2002009702-A2 | USE OF INDOLE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR REDUCING INTRACULAR PRESSURE | INSPIRE PHARMACEUTICALS, INC. (US) | 2002-02-07 | — | — | WO | disclosed |
| US-4839377-A | TREATMENT OF MIGRAINE | GLAXO GROUP LIMITED (GB) | 1989-06-13 | — | — | US | disclosed |
| US-4803218-A | HYPOTENSIVE AGENTS | MCNEILAB, INC. (US) | 1989-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198803-A1 | Such as 5-(methoxycarbonylamino)-N - acetyltryptamine; therapy for ocular hypertension; vision defects | MTNR1A, MTNR1B, MC5R | HTR1A 16/4885HTR1D 23/4885HTR1B 41/4885 |
| US-20020037887-A1 | Method for reducing intraocular pressure using indole derivatives | MTNR1A, MTNR1B, MC5R | HTR1A 33/4885HTR1D 72/4885HTR1B 104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.