Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.57 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.51 |
| ▸ | CCR5 | P51681 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8572593 | 0.98 | CCR2 (0.56) | CCR2KCNA3OPRL1CCR5ALDH1A1 | |
| SCHEMBL8565906 | 0.87 | CCR2 (0.54) | CCR2KCNA3OPRL1CCR5ALDH1A1 | |
| SCHEMBL8572588 | 0.86 | CCR2 (0.53) | CCR2KCNA3OPRL1CCR5ALDH1A1 | |
| SCHEMBL6775700 | 0.85 | LMNA (0.54) | CCR2KCNA3OPRL1CCR5ALDH1A1 | |
| SCHEMBL6770020 | 0.80 | KMT2A (0.58) | CCR2KCNA3ALDH1A1 | |
| Prozapine SCHEMBL25765 | 0.80 | ALDH1A1 (0.66) | CCR2KCNA3OPRL1ALDH1A1CYP2D6 | |
| Fenpiprane SCHEMBL24507 | 0.80 | ALDH1A1 (0.66) | CCR2KCNA3OPRL1ALDH1A1CYP2D6 | |
| Fenpiprane SCHEMBL11585426 | 0.79 | ALDH1A1 (0.64) | CCR2KCNA3OPRL1ALDH1A1CYP2D6 | |
| Prozapine SCHEMBL365642 | 0.79 | ALDH1A1 (0.64) | CCR2KCNA3OPRL1ALDH1A1CYP2D6 | |
| SCHEMBL6770148 | 0.78 | CCR2 (0.81) | CCR2KCNA3OPRL1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686353-B1 | PREVENTING BLOOD MONOCYTES AND LYMPHOCYTES FROM INFILTRATING TISSUE | TEIJIN INTELLECTUAL PROPERTY CENTER LIMITED (JP) | 2004-02-03 | — | — | US | disclosed |
| EP-0914319-B1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LTD (JP) | 2001-11-21 | — | — | EP | disclosed |
| EP-0914319-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1999-05-12 | — | — | EP | disclosed |
| WO-1997044329-A9 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | — | 1998-03-12 | — | — | WO | disclosed |
| WO-1997044329-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1997-11-27 | — | — | WO | disclosed |