SCHEMBL6770148

SCHEMBL6770148

c1ccc(CN2CCCN(CCC(c3ccccc3)c3ccccc3)CC2)cc1

nearest known ligand 0.81

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 4/20 0.81
SIGMAR1 Q99720 2/20 0.58
MC4R P32245 1/20 0.54
KCNA3 P22001 1/20 0.54
KDM4E B2RXH2 1/20 0.54
CCR3 P51677 1/20 0.53
ALDH1A1 P00352 1/20 0.52
CHKA P35790 1/20 0.51
OPRL1 P41146 1/20 0.50
CYP2D6 P10635 1/20 0.50
ATM Q13315 1/20 0.50
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11848227 0.95 CCR2 (0.73) CCR2SIGMAR1MC4RKCNA3KDM4E
Hydrochloric Acid SCHEMBL11838606 0.93 CCR2 (0.71) CCR2SIGMAR1MC4RKCNA3KDM4E
SCHEMBL3061933 0.84 SIGMAR1 (0.75) CCR2SIGMAR1MC4RCCR3CHKA
SCHEMBL6770934 0.84 CCR2 (1.00) CCR2SIGMAR1KDM4EALDH1A1
SCHEMBL6768880 0.84 CCR2 (0.64) CCR2KCNA3ATMMEN1KMT2A
Fumaric Acid SCHEMBL11848798 0.83 CCR2 (0.59) CCR2SIGMAR1KCNA3KDM4EALDH1A1
Fumaric Acid SCHEMBL11848804 0.83 CCR2 (0.59) CCR2SIGMAR1KCNA3KDM4EALDH1A1
Prozapine SCHEMBL25765 0.83 ALDH1A1 (0.66) CCR2SIGMAR1KCNA3ALDH1A1OPRL1
Fenpiprane SCHEMBL24507 0.83 ALDH1A1 (0.66) CCR2SIGMAR1KCNA3ALDH1A1OPRL1
SCHEMBL1043563 0.82 SIGMAR1 (0.86) SIGMAR1MC4RCCR3CHKAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6686353-B1 PREVENTING BLOOD MONOCYTES AND LYMPHOCYTES FROM INFILTRATING TISSUE TEIJIN INTELLECTUAL PROPERTY CENTER LIMITED (JP) 2004-02-03 US disclosed
EP-0914319-B1 DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS TEIJIN LTD (JP) 2001-11-21 EP disclosed
EP-0914319-A1 DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS TEIJIN LIMITED (JP) 1999-05-12 EP disclosed
WO-1997044329-A1 DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS TEIJIN LIMITED (JP) 1997-11-27 WO disclosed