Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 4/20 | 0.53 |
| ▸ | HTR1B | P28222 | 4/20 | 0.53 |
| ▸ | HTR1A | P08908 | 12/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR1E | P28566 | 1/20 | 0.47 |
| ▸ | HTR1F | P30939 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR5A | P47898 | 1/20 | 0.47 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047899 | 0.92 | HTR1D (0.53) | HTR1DHTR1BHTR1AHTR2AHTR7 | |
| Avitriptan SCHEMBL29633456 | 0.86 | HTR1D (0.55) | HTR1DHTR1BHTR1AHTR2AHTR7 | |
| Avitriptan SCHEMBL147315 | 0.86 | HTR1D (0.55) | HTR1DHTR1BHTR1AHTR2AHTR7 | |
| Avitriptan SCHEMBL4352074 | 0.85 | HTR1D (0.54) | HTR1DHTR1BHTR1AHTR2AHTR7 | |
| SCHEMBL9045692 | 0.84 | HTR1D (0.48) | HTR1DHTR1BHTR1AHTR2AHTR7 | |
| SCHEMBL9047985 | 0.84 | HTR1A (0.69) | HTR1AHTR2AADRA2AADRA2BADRA2C | |
| SCHEMBL9049477 | 0.83 | HTR1A (0.66) | HTR1AHTR7SLC6A4KCNH2 | |
| SCHEMBL6765833 | 0.83 | HTR1A (0.48) | HTR1AHTR7ADRA2AADRA2BADRA2C | |
| SCHEMBL9046438 | 0.82 | HTR1D (0.56) | HTR1DHTR1BHTR1AHTR2AHTR7 | |
| SCHEMBL9045333 | 0.81 | HTR1D (0.49) | HTR1DHTR1BHTR1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714896-A1 | INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF MIGRAINE, COMPOSITION AND UTILIZATION | VITA-INVEST, S.A. (ES) | 1996-06-05 | — | — | EP | claimed |
| US-20040023948-A1 | Fast-dispersing dosage form containing 5-HT1 agonists | CATALENT USA PAINTBALL, INC. | 2004-02-05 | — | — | US | disclosed |
| EP-0969842-A1 | PHARMACEUTICAL COMPOSITION | R.P. Scherer Limited (GB) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998042344-A1 | PHARMACEUTICAL COMPOSITION | R. P. SCHERER LIMITED (GB) | 1998-10-01 | — | — | WO | disclosed |
| EP-0714896-A1 | INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF MIGRAINE, COMPOSITION AND UTILIZATION | VITA-INVEST, S.A. (ES) | 1996-06-05 | — | — | EP | disclosed |