Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CHKA | P35790 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990607 | 0.93 | MAOB (0.57) | MAOBCYP1A2IDO1ALDH1A1CHKA | |
| SCHEMBL128405 | 0.92 | — | — | |
| Ammonia Solution, Strong SCHEMBL267275 | 0.89 | IDO1 (0.50) | IDO1ALDH1A1NPC1LMNAPOLB | |
| Ethane SCHEMBL27746361 | 0.89 | IDO1 (0.50) | IDO1ALDH1A1NPC1LMNAPOLB | |
| Methylamine SCHEMBL10855430 | 0.86 | TAAR1 (0.50) | IDO1ALDH1A1NPC1LMNAPOLB | |
| SCHEMBL1702558 | 0.86 | TP53 (0.56) | ALDH1A1SMN1; SMN2TP53EGFRTAAR1 | |
| SCHEMBL2776957 | 0.86 | TP53 (0.56) | ALDH1A1SMN1; SMN2TP53EGFRTAAR1 | |
| SCHEMBL23658935 | 0.84 | PTGS2 (0.52) | MAOBCYP1A2ALDH1A1NPC1LMNA | |
| Formaldehyde SCHEMBL28039019 | 0.84 | ALDH1A1 (0.50) | IDO1ALDH1A1NPC1LMNAPOLB | |
| SCHEMBL14071527 | 0.83 | CHKA (0.58) | MAOBALDH1A1CHKAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174584-A1 | Antibiotic Compounds | UNIVERSITEIT LEIDEN (NL) | 2023-06-08 | — | — | US | disclosed |
| EP-3166961-B1 | N- (HYDROPHOBE-SUBSTITUTED) VANCOSAMINYL [PSI[C(=NH) NH] TPG4] VANCOMYCIN AND [PSI[CH2NH]TPG4] VANCOMYCIN | SCRIPPS RESEARCH INST (US) | 2023-06-07 | — | — | EP | disclosed |
| WO-2022050369-A1 | LIPOSOME PREPARATION CONTAINING ANTIBACTERIAL DRUG | 国立大学法人大阪大学 | 2022-03-10 | — | — | WO | disclosed |
| EP-3452464-B1 | PYRAZOLE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USE THEREOF | HOFFMANN LA ROCHE (CH) | 2021-12-15 | — | — | EP | disclosed |
| EP-2651403-B1 | USE OF LP-PLA2 INHIBITORS IN THE TREATMENT AND PREVENTION OF EYE DISEASES | GLAXO GROUP LTD (GB) | 2020-12-02 | — | — | EP | disclosed |
| WO-2018081797-A1 | PERIPHERAL MODIFICATIONS ON POCKET-REDESIGNED VANCOMYCIN ANALOGS SYNERGISTICALLY IMPROVE ANTIMICROBIAL POTENCY AND DURABILITY | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-05-03 | — | — | WO | disclosed |
| US-20180044343-A1 | BICYCLIC IMIDAZOLO DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2018-02-15 | — | — | US | disclosed |
| US-20170362283-A1 | NISIN-BASED COMPOUNDS AND USE THEREOF IN THE TREATMENT OF BACTERIAL INFECTIONS | UNIVERSITEIT UTRECHT HOLDING B.V. (NL) | 2017-12-21 | — | — | US | disclosed |
| WO-2017191098-A1 | PYRAZOLE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-11-09 | — | — | WO | disclosed |
| US-9802904-B2 | Inhibitors of the USP1/UAF1 deubiquitinase complex and uses thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2017-10-31 | — | — | US | disclosed |
| US-7259141-B2 | Vancomycin analogs and methods thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259141-B2 | Vancomycin analogs and methods thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-08-21 | — | — | US | disclosed |
| WO-2007084507-A2 | [ψ[CH2NH]PG4] GLYCOPEPTIDE ANTIBIOTIC ANALOGS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-26 | — | — | WO | disclosed |
| WO-2007053193-A2 | UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-05-10 | — | — | WO | disclosed |
| WO-2005018743-A1 | USE OF AN ECHINOCANDIN ANTIFUNGAL AGENT IN COMBINATION WITH A GLYCOPEPTIDE ANTIBACTERIAL AGENT | THERAVANCE, INC. (US) | 2005-03-03 | — | — | WO | disclosed |
| WO-2004110473-A1 | USE OF A POLYENE MACROLIDE ANTIFUNGAL AGENT IN COMBINATION WITH A GLYCOPEPTIDE ANTIBACTERIAL AGENT | THERAVANCE, INC. (US) | 2004-12-23 | — | — | WO | disclosed |
| US-4027041-A | Ethyl- and vinylbenzenes as antithrombotic agents | ELI LILLY AND COMPANY (US) | 1977-05-31 | — | — | US | disclosed |
| US-4024284-A | Ethyl- and vinylbenzenes as anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-17 | — | — | US | disclosed |
| US-3975542-A | Ethyl- and vinylbenzenes as antithromobiotic agents | ELI LILLY AND COMPANY (US) | 1976-08-17 | — | — | US | disclosed |
| US-3975543-A | Ethyl- and vinylbenzenes as anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1976-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044343-A1 | BICYCLIC IMIDAZOLO DERIVATIVE | PDE3A, PDE2A, PDE5A | MAOB 210/4885CYP1A2 677/4885IDO1 572/4885 |
| US-20170362283-A1 | NISIN-BASED COMPOUNDS AND USE THEREOF IN THE TREATMENT OF BACTERIAL INFECTIONS | NISCH, VIP, NGLY1 | MAOB 3218/4885CYP1A2 4791/4885IDO1 1023/4885 |
| US-20230174584-A1 | Antibiotic Compounds | RPN1, STT3B, RPN2 | MAOB 3806/4885CYP1A2 840/4885IDO1 2949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.