Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 3/20 | 0.46 |
| ▸ | HAT1 | O14929 | 3/20 | 0.44 |
| ▸ | EP300 | Q09472 | 3/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769653 | 0.81 | ALDH1A1 (0.61) | ALDH1A1LMNA | |
| SCHEMBL20787986 | 0.80 | PDE4A (0.47) | ALDH1A1ADRA1DEGFROXER1 | |
| SCHEMBL22450724 | 0.80 | KCNH2 (0.56) | CREBBPKCNH2ALDH1A1POLBCNR2 | |
| SCHEMBL31158213 | 0.79 | KCNH2 (0.49) | CREBBPKCNH2ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL20789160 | 0.78 | ADRA1D (0.43) | ALDH1A1ADRA1DEGFROXER1LMNA | |
| SCHEMBL27546953 | 0.78 | L3MBTL1 (0.50) | ALDH1A1SMN1; SMN2POLBCNR2CNR1 | |
| SCHEMBL8358588 | 0.78 | LMNA (0.62) | ALDH1A1SMN1; SMN2CNR2CNR1LMNA | |
| SCHEMBL9572754 | 0.75 | KCNH2 (0.59) | KCNH2ALDH1A1POLBLMNA | |
| SCHEMBL8358799 | 0.75 | NR4A2 (0.53) | ALDH1A1LMNA | |
| SCHEMBL5208684 | 0.74 | POLB (0.57) | CREBBPALDH1A1SMN1; SMN2POLBCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716605-B2 | Indole derivatives having an antiviral activity | SHIONOGI & CO., LTD. (JP) | 2004-04-06 | — | — | US | disclosed |
| US-20030181499-A1 | Indole derivatives having an antiviral activity | FUJISHITA TOSHIO (JP) | 2003-09-25 | — | — | US | disclosed |
| US-6506787-B2 | Aids therapy | SHIONOGI & CO., LTD. (JP) | 2003-01-14 | — | — | US | disclosed |
| US-20020019434-A1 | Indole derivatives having an antiviral activity | FUJISHITA TOSHIO (JP) | 2002-02-14 | — | — | US | disclosed |
| US-6333323-B1 | AS ANTI-HUMAN IMMUNODEFICIENCY VIRUS (HIV) DRUGS | SHIONOGI & CO., LTD. (JP) | 2001-12-25 | — | — | US | disclosed |
| EP-1069111-A1 | INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2001-01-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019434-A1 | Indole derivatives having an antiviral activity | IDO1, IDO2, RCOR1 | CREBBP 2658/4885KCNH2 3419/4885ALDH1A1 2014/4885 |
| US-20030181499-A1 | Indole derivatives having an antiviral activity | IDO1, RCOR1, IDO2 | CREBBP 2445/4885KCNH2 3390/4885ALDH1A1 1891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.