Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | USP2 | O75604 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6767179 | 0.86 | POLB (0.35) | KDM4EHSD17B10ALDH1A1HPGDALPL | |
| SCHEMBL6772430 | 0.85 | CCNA2 (0.44) | KDM4EALDH1A1HPGDCCNA2CDK2 | |
| SCHEMBL6770739 | 0.85 | CCNA2 (0.45) | ALDH1A1CCNA2CDK2SRCMEN1 | |
| SCHEMBL6766539 | 0.83 | CCNA2 (0.35) | CCNA2CDK2SRCMEN1KMT2A | |
| SCHEMBL6776854 | 0.82 | PTGS1 (0.42) | KDM4EHSD17B10ALDH1A1HPGDCCNA2 | |
| SCHEMBL6775773 | 0.81 | CCNA2 (0.39) | ALDH1A1CCNA2CDK2MAPTMEN1 | |
| SCHEMBL6771336 | 0.81 | CCNA2 (0.37) | CCNA2CDK2SRCMEN1KMT2A | |
| SCHEMBL6767158 | 0.80 | CCNA2 (0.37) | CCNA2CDK2MEN1KMT2ALMNA | |
| SCHEMBL6772549 | 0.80 | CCNA2 (0.35) | KDM4EALDH1A1CCNA2CDK2MAPT | |
| SCHEMBL7534112 | 0.79 | OPRM1 (0.50) | KDM4EHSD17B10ALDH1A1HPGDALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |