Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772419 | 0.88 | SRC (0.39) | ALDH1A1LMNASRCMEN1KMT2A | |
| SCHEMBL6165346 | 0.88 | ALDH1A1 (0.40) | ALDH1A1LMNAMEN1KMT2ADHODH | |
| SCHEMBL6766574 | 0.88 | ALDH1A1 (0.39) | ALDH1A1LMNAMAPTKMT2ADHODH | |
| SCHEMBL6771042 | 0.86 | ALDH1A1 (0.44) | ALDH1A1LMNAMAPTSRCMEN1 | |
| SCHEMBL6769465 | 0.84 | ALDH1A1 (0.36) | ALDH1A1LMNAMAPTKMT2ADHODH | |
| SCHEMBL6769819 | 0.84 | OPRM1 (0.43) | ALDH1A1LMNAMAPTSRCMEN1 | |
| SCHEMBL6770749 | 0.83 | SRC (0.35) | ALDH1A1LMNASRCMEN1KMT2A | |
| SCHEMBL6767259 | 0.83 | SRC (0.40) | ALDH1A1LMNAMAPTSRCMEN1 | |
| SCHEMBL6767248 | 0.82 | DHODH (0.35) | ALDH1A1LMNAMAPTKMT2ADHODH | |
| SCHEMBL6770751 | 0.82 | OPRM1 (0.45) | ALDH1A1SRCMEN1KMT2ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |