Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168419 | 0.87 | DHODH (0.42) | OPRM1DHODHKMT2AMEN1ALDH1A1 | |
| SCHEMBL6770575 | 0.87 | GPBAR1 (0.39) | OPRM1SRCDHODHKMT2AMEN1 | |
| SCHEMBL6769819 | 0.86 | OPRM1 (0.43) | OPRM1SRCDHODHKMT2AMEN1 | |
| SCHEMBL6767259 | 0.85 | SRC (0.40) | SRCDHODHKMT2AMEN1ALDH1A1 | |
| SCHEMBL6771222 | 0.85 | OPRM1 (0.47) | OPRM1SRCCNR1KMT2AMEN1 | |
| SCHEMBL6770539 | 0.83 | SRC (0.39) | OPRM1SRCDHODHKMT2AMEN1 | |
| SCHEMBL6769850 | 0.83 | OPRM1 (0.38) | OPRM1DHODHKMT2AMEN1ALDH1A1 | |
| SCHEMBL6772419 | 0.83 | SRC (0.39) | SRCDHODHKMT2AMEN1ALDH1A1 | |
| SCHEMBL6770490 | 0.82 | ALDH1A1 (0.42) | SRCDHODHKMT2AMEN1ALDH1A1 | |
| SCHEMBL6776388 | 0.81 | OPRM1 (0.38) | OPRM1SRCDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |