Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | SLC5A1 | P13866 | 4/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772144 | 0.90 | RIPK2 (0.36) | RIPK2SLC5A1MAPTPDE4APDE4B | |
| SCHEMBL6770749 | 0.89 | SRC (0.35) | SLC5A1DHODHSRCSMN1; SMN2MEN1 | |
| SCHEMBL6772551 | 0.89 | DHODH (0.37) | RIPK2DHODHMAPTMGLLPDE4A | |
| SCHEMBL6167945 | 0.88 | DHODH (0.37) | DHODHSMN1; SMN2 | |
| SCHEMBL6778055 | 0.84 | SRC (0.43) | RIPK2MAPTPDE4APDE4BPDE4C | |
| SCHEMBL6766574 | 0.84 | ALDH1A1 (0.39) | SLC5A1DHODHMAPTCCR1MGLL | |
| SCHEMBL6766674 | 0.84 | RIPK2 (0.46) | RIPK2DHODHMAPTCCR1MGLL | |
| SCHEMBL6771525 | 0.83 | OPRM1 (0.50) | SRC | |
| SCHEMBL6771327 | 0.82 | DHODH (0.32) | DHODH | |
| SCHEMBL6770505 | 0.81 | OPRM1 (0.46) | DHODHMAPTMGLLSRCRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |