Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 5/20 | 0.39 |
| ▸ | CTSS | P25774 | 4/20 | 0.38 |
| ▸ | CTSK | P43235 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 4/20 | 0.37 |
| ▸ | MMP1 | P03956 | 3/20 | 0.37 |
| ▸ | PARG | Q86W56 | 5/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 2/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 3/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23693960 | 0.96 | POLB (0.42) | POLBHPGDCTSLCTSSCTSK | |
| SCHEMBL23693187 | 0.89 | HPGD (0.53) | POLBHPGDCTSLCTSSCTSK | |
| SCHEMBL29887216 | 0.89 | HPGD (0.53) | POLBHPGDCTSLCTSSCTSK | |
| SCHEMBL6771478 | 0.86 | MMP1 (0.47) | MMP13MMP1MMP12 | |
| SCHEMBL23693947 | 0.84 | USP2 (0.51) | MMP13PARGUSP2HTTSMN1; SMN2 | |
| SCHEMBL6772621 | 0.83 | USP2 (0.49) | MMP13PARGUSP2HTTSMN1; SMN2 | |
| SCHEMBL23693537 | 0.81 | MMP12 (0.42) | MMP13MMP1PARGUSP2HTT | |
| SCHEMBL23673553 | 0.80 | USP2 (0.51) | MMP13USP2HTTSMN1; SMN2PLG | |
| SCHEMBL23693711 | 0.79 | CTSL (0.56) | POLBHPGDCTSLCTSSCTSK | |
| SCHEMBL23693951 | 0.79 | POLB (0.44) | POLBHPGDCTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021147882-A1 | DIBENZOFURAN DERIVATIVE CATHEPSIN K INHIBITOR, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 深圳信立泰药业股份有限公司 | 2021-07-29 | — | — | WO | disclosed |