Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.39 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.39 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772063 | 0.87 | OPRM1 (0.48) | SMN1; SMN2RAB9AKMT2AMAPTHTT | |
| SCHEMBL6771222 | 0.86 | OPRM1 (0.47) | SMN1; SMN2KMT2AMAPTL3MBTL1MEN1 | |
| SCHEMBL6770575 | 0.86 | GPBAR1 (0.39) | GPBAR1NSD2NSD1NSD3LPAR5 | |
| SCHEMBL6168193 | 0.84 | ABCG2 (0.42) | HPGDSMN1; SMN2RAB9AKMT2AMAPT | |
| SCHEMBL6775862 | 0.83 | ABCG2 (0.39) | HPGDSMN1; SMN2RAB9AKMT2AMAPT | |
| SCHEMBL6766708 | 0.83 | RIPK2 (0.48) | HPGDSMN1; SMN2RAB9AKMT2AMAPT | |
| SCHEMBL6772956 | 0.83 | SRC (0.49) | GPBAR1NSD2NSD1NSD3LPAR5 | |
| SCHEMBL6766537 | 0.81 | ALDH1A1 (0.41) | HPGDSMN1; SMN2RAB9AKMT2AMAPT | |
| SCHEMBL6771516 | 0.81 | OPRM1 (0.58) | SRCOPRM1 | |
| SCHEMBL6771827 | 0.81 | ABCG2 (0.37) | HPGDSMN1; SMN2RAB9AKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |