Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772323 | 0.87 | GPBAR1 (0.41) | OPRM1SRCSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6777711 | 0.86 | OPRM1 (0.45) | OPRM1SRCSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6775862 | 0.86 | ABCG2 (0.39) | SRCSMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL6766708 | 0.86 | RIPK2 (0.48) | OPRM1SRCSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6770505 | 0.85 | OPRM1 (0.46) | OPRM1SRCSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6167870 | 0.84 | ALDH1A1 (0.49) | OPRM1SMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL6766537 | 0.84 | ALDH1A1 (0.41) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL6771827 | 0.83 | ABCG2 (0.37) | SRCSMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL6770366 | 0.81 | SRC (0.56) | OPRM1SRCSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6772144 | 0.79 | RIPK2 (0.36) | SRCSMN1; SMN2RAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |