Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770768 | 0.86 | SRC (0.41) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6772063 | 0.86 | OPRM1 (0.48) | MAPTNPSR1SMN1; SMN2RAB9AHTT | |
| SCHEMBL6766674 | 0.86 | RIPK2 (0.46) | RIPK2MAPTHPGDALDH1A1NPSR1 | |
| SCHEMBL6164677 | 0.85 | ABCG2 (0.41) | MAPTHPGDALDH1A1MAPK13MAPK12 | |
| SCHEMBL6772323 | 0.83 | GPBAR1 (0.41) | MAPTHPGDALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL6775862 | 0.82 | ABCG2 (0.39) | MAPTHPGDALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL6771869 | 0.82 | RIPK2 (0.50) | RIPK2MAPTHPGDALDH1A1NPSR1 | |
| SCHEMBL6772144 | 0.81 | RIPK2 (0.36) | RIPK2MAPTHPGDSMN1; SMN2RAB9A | |
| SCHEMBL6766537 | 0.81 | ALDH1A1 (0.41) | MAPTHPGDALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL6767112 | 0.80 | OPRM1 (0.58) | RIPK2SRCOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |