Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 2/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 3/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690216 | 0.94 | PLA2G2A (0.43) | PLA2G2AALDH1A1CCR2PGRPPARG | |
| SCHEMBL6774933 | 0.93 | PLA2G2A (0.42) | PLA2G2AACMSDPLA2G10PLA2G1BSLCO1B1 | |
| SCHEMBL6776773 | 0.92 | PLA2G2A (0.42) | PLA2G2AALDH1A1CCR2PGRPPARG | |
| SCHEMBL6776758 | 0.90 | PLA2G2A (0.50) | PLA2G2AALDH1A1CCR2PGRPLA2G1B | |
| SCHEMBL6770388 | 0.90 | PLA2G2A (0.41) | PLA2G2AALDH1A1CCR2PGRPPARG | |
| SCHEMBL6773052 | 0.88 | PLA2G2A (0.50) | PLA2G2AALDH1A1CCR2PGRPLA2G1B | |
| SCHEMBL6892182 | 0.88 | DRD2 (0.43) | PLA2G2AALDH1A1PPARGALOX5 | |
| SCHEMBL6774857 | 0.88 | FAAH (0.43) | PLA2G2ACCR2PPARGADRA1D | |
| SCHEMBL6694433 | 0.88 | PLA2G2A (0.46) | PLA2G2AALDH1A1PLA2G10PLA2G1BL3MBTL1 | |
| SCHEMBL6776710 | 0.87 | PLA2G2A (0.41) | PLA2G2APLA2G1BL3MBTL1ATG4BADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |