SCHEMBL6773548

SCHEMBL6773548

Cc1nc(N)c2ncn(CCCCNC(=O)c3ccc4ccccc4c3)c2c1C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 5/20 0.49
HDAC1 Q13547 5/20 0.49
HDAC4 P56524 4/20 0.49
HDAC7 Q8WUI4 4/20 0.49
HDAC2 Q92769 4/20 0.49
HDAC10 Q969S8 4/20 0.49
HDAC11 Q96DB2 4/20 0.49
HDAC8 Q9BY41 4/20 0.49
HDAC6 Q9UBN7 4/20 0.49
HDAC9 Q9UKV0 4/20 0.49
HDAC5 Q9UQL6 4/20 0.49
DRD3 P35462 11/20 0.48
DRD2 P14416 11/20 0.48
ADRA1A P35348 9/20 0.48
HRH4 Q9H3N8 1/20 0.46
DRD4 P21917 3/20 0.44
SLC6A4 P31645 3/20 0.44
SLC6A2 P23975 2/20 0.44
HTR1A P08908 3/20 0.44
ADRA2A P08913 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6768483 0.89 DRD3 (0.44) HDAC3HDAC1HDAC4HDAC7HDAC2
SCHEMBL6772103 0.86 MCHR1 (0.51) DRD3DRD2DRD4MEN1TP53
SCHEMBL6774052 0.86 POLB (0.43) HDAC3HDAC1HDAC4HDAC7HDAC2
SCHEMBL3867629 0.85 HDAC3 (0.49) HDAC3HDAC1HDAC4HDAC7HDAC2
SCHEMBL6773542 0.84 TP53BP1 (0.48) HDAC3HDAC1HDAC2DRD3DRD2
SCHEMBL6769799 0.84 MCHR1 (0.50) HDAC3DRD3
SCHEMBL6773439 0.83 TRPV1 (0.44) HDAC3HDAC1HDAC2
SCHEMBL5749804 0.82 HDAC3 (0.46) HDAC3HDAC1HDAC4HDAC7HDAC2
SCHEMBL6779944 0.81 HDAC3 (0.48) HDAC3HDAC1HDAC4HDAC7HDAC2
SCHEMBL6098139 0.81 DYRK1A (0.37) HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6720333-B2 IMMUNE RESPONSE MODIFIERS; CYTOKINE BIOSYNTHESIS; VIRAL AND NEOPLASTIC DISEASES; N-(4-(4-AMINO-6,7-DIMETHYL-1H-IMIDAZO (4,5-C)PYRIDIN-1-YL)BUTYL)BENZAMIDE 3M INNOVATIVE PROPERTIES COMPANY 2004-04-13 US claimed