Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.37 |
| ▸ | ITGAV | P06756 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 4/20 | 0.36 |
| ▸ | NMT1 | P30419 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180441 | 0.83 | ITGB3 (0.56) | ITGB3ITGAVALDH1A1 | |
| SCHEMBL6773547 | 0.83 | PFKFB3 (0.40) | ITGB3ITGAVNMT1NAMPT | |
| SCHEMBL6773550 | 0.78 | FFAR1 (0.48) | ITGB3ITGAVSMN1; SMN2NMT1HDAC1 | |
| SCHEMBL3772416 | 0.70 | HDAC1 (0.72) | HDAC1 | |
| SCHEMBL4605920 | 0.70 | GAA (0.53) | ALDH1A1MEN1KMT2A | |
| SCHEMBL28404275 | 0.68 | GBA1 (0.61) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3802084 | 0.68 | HDAC1 (0.46) | HDAC1 | |
| SCHEMBL14597960 | 0.67 | TDP1 (0.54) | LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4637957 | 0.67 | SFRP1 (0.47) | ALDH1A1KMT2A | |
| SCHEMBL14290772 | 0.65 | CTSK (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677360-B2 | TREATMENT AND PROPHYLAXIS OF CANCER, ARTERIOSCLEROSIS, RESTENOSIS, OSTEOPOROSIS AND EYE DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 2004-01-13 | — | — | US | disclosed |