SCHEMBL677398

SCHEMBL677398

CNc1ccc(C(c2ccc(NC(=O)c3cccc(C(=O)Nc4ccc(O)c(NC(=O)c5cccc(C(C)=O)c5)c4)c3)cc2)(C(F)(F)F)C(F)(F)F)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.48
POLB P06746 2/20 0.48
BRAF P15056 4/20 0.45
MAPT P10636 2/20 0.44
RXFP1 Q9HBX9 1/20 0.44
PTGS1 P23219 2/20 0.44
NR1H4 Q96RI1 1/20 0.43
HDAC1 Q13547 1/20 0.43
MEN1 O00255 2/20 0.42
KCNK3 O14649 1/20 0.42
CSF1R P07333 2/20 0.42
KCNMA1 Q12791 2/20 0.42
ADRB2 P07550 1/20 0.41
GAA P10253 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
PABPC1 P11940 1/20 0.41
DUSP3 P51452 1/20 0.41
PTPN5 P54829 1/20 0.41
PTPN11 Q06124 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL677399 0.94 KDR (0.44) KMT2APOLBBRAFRXFP1HDAC1
SCHEMBL677965 0.87 KCNMA1 (0.45) KMT2APOLBMAPTRXFP1NR1H4
SCHEMBL676652 0.87 HDAC1 (0.46) KMT2APOLBRXFP1NR1H4HDAC1
SCHEMBL1108314 0.84 KCNMA1 (0.52) KMT2APOLBMAPTRXFP1HDAC1
SCHEMBL13955796 0.84 KCNMA1 (0.46) KMT2APOLBMAPTRXFP1NR1H4
SCHEMBL677388 0.83 AR (0.47) KMT2APOLBBRAFNR1H4HDAC1
SCHEMBL1108328 0.83 AR (0.53) KMT2APOLBBRAFRXFP1NR1H4
SCHEMBL676656 0.83 AR (0.53) KMT2APOLBBRAFRXFP1NR1H4
SCHEMBL676658 0.83 KMT2A (0.49) KMT2APOLBMAPTRXFP1HDAC1
SCHEMBL677382 0.81 MAPT (0.45) KMT2APOLBBRAFMAPTRXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7906213-B2 Epoxy resin curable composition for prepreg ADEKA CORPORATION (JP) 2011-03-15 US disclosed
US-20090030147-A1 Epoxy Resin Curable Composition For Prepreg ADEKA CORPORATION (JP) 2009-01-29 US disclosed