Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TPMT | P51580 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6780474 | 0.80 | TTR (0.43) | TSHRALDH1A1HPGDALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL6783703 | 0.79 | TTR (0.42) | TSHRALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL6777843 | 0.78 | LCK (0.44) | TSHRACHE | |
| SCHEMBL6777007 | 0.78 | TSHR (0.50) | TSHRAPOBEC3AHTTAPOBEC3GNCOA1 | |
| SCHEMBL571771 | 0.77 | TSHR (0.54) | TSHRAPOBEC3AHTTAPOBEC3GSMN1; SMN2 | |
| SCHEMBL571770 | 0.77 | TSHR (0.54) | TSHRAPOBEC3AHTTAPOBEC3GSMN1; SMN2 | |
| SCHEMBL7836306 | 0.74 | ALDH1A1 (0.46) | TSHRAPOBEC3AHTTAPOBEC3GNCOA1 | |
| SCHEMBL6783358 | 0.73 | ACHE (0.42) | TSHRHTTSMN1; SMN2ALDH1A1ACHE | |
| SCHEMBL6778049 | 0.71 | FABP3 (0.43) | — | |
| Hydrochloric Acid SCHEMBL6378948 | 0.70 | TPMT (0.39) | HTTSMN1; SMN2ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831199-B1 | In order to avoid bleeding side-effects when treating the conditions associated with integrin alpha v beta 3, it is beneficial to have compounds which are selective antagonists for alpha v beta 3 versus alpha IIb beta 3 | G. D. SEARLE & CO. | 2004-12-14 | — | — | US | disclosed |